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dc.contributor.author
Martins, Amanda Weege S.
dc.contributor.author
Silveira, Tony L. R.
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Remião, Mariana H.
dc.contributor.author
Domingues, William Borges
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Dellagostin, Eduardo N.
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Varela Junior, Antônio Sergio
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Corcini, Carine D.
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Costa, Patrícia G.
dc.contributor.author
Bianchini, Adalto
dc.contributor.author
Somoza, Gustavo Manuel
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dc.contributor.author
Robaldo, Ricardo B.
dc.contributor.author
Campos, Vinicius Farias
dc.date.available
2021-07-23T15:53:16Z
dc.date.issued
2021-07-06
dc.identifier.citation
Martins, Amanda Weege S.; Silveira, Tony L. R.; Remião, Mariana H.; Domingues, William Borges; Dellagostin, Eduardo N.; et al.; Acute exposition to Roundup Transorb® induces systemic oxidative stress and alterations in the expression of newly sequenced genes in silverside fish (Odontesthes humensis); Springer Heidelberg; Environmental Science and Pollution Research; 2021; 6-7-2021; 1-13
dc.identifier.issn
0944-1344
dc.identifier.uri
http://hdl.handle.net/11336/136757
dc.description.abstract
Roundup Transorb® (RDT) is a glyphosate-based herbicide commonly used in agricultural practices worldwide. This herbicide exerts negative effects on the aquatic ecosystem and affects bioenergetic and detoxification pathways, oxidative stress, and cell damage in marine organisms. These effects might also occur at the transcriptional level; however, the expression of genes associated with oxidative stress has not been studied well. Odontesthes humensis is a native Brazilian aquatic species naturally distributed in the habitats affected by pesticides, including Roundup Transorb® (RDT). This study evaluated the toxic effects of short-term exposure to RDT on O. humensis. Moreover, the genes related to oxidative stress were sequenced and characterized, and their expressions in the gills, hepatopancreas, kidneys, and brain of the fish were quantified by quantitative reverse transcription-polymerase chain reaction. The animals were exposed to two environmentally relevant concentrations of RDT (2.07 and 3.68 mg L−1) for 24 h. Lipid peroxidation, reactive oxygen species (ROS), DNA damage, and apoptosis in erythrocytes were quantified by flow cytometry. The expression of the target genes was modulated in most tissues in the presence of the highest tested concentration of RDT. In erythrocytes, the levels of lipid peroxidation, ROS, and DNA damage were increased in the presence of both the concentrations of RDT, whereas cell apoptosis was increased in the group exposed to 3.68 mg L−1 RDT. In conclusion, acute exposure to RDT caused oxidative stress in the fish, induced negative effects on cells, and modulated the expression of genes related to the enzymatic antioxidant system in O. humensis.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer Heidelberg
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
AQUATIC ECOSYSTEM
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GENE EXPRESSION
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GLYPHOSATE
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HERBICIDE
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OXIDATIVE DAMAGE
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REACTIVE OXYGEN SPECIES
dc.subject.classification
Zoología, Ornitología, Entomología, Etología
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Acute exposition to Roundup Transorb® induces systemic oxidative stress and alterations in the expression of newly sequenced genes in silverside fish (Odontesthes humensis)
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-07-19T18:44:39Z
dc.journal.volume
2021
dc.journal.pagination
1-13
dc.journal.pais
Alemania
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dc.journal.ciudad
Heidelberg
dc.description.fil
Fil: Martins, Amanda Weege S.. Universidade Federal de Pelotas; Brasil
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Fil: Silveira, Tony L. R.. Universidade Federal de Pelotas; Brasil. Universidade Federal do Rio Grande; Brasil
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Fil: Remião, Mariana H.. Universidade Federal de Pelotas; Brasil
dc.description.fil
Fil: Domingues, William Borges. Universidade Federal de Pelotas; Brasil
dc.description.fil
Fil: Dellagostin, Eduardo N.. Universidade Federal de Pelotas; Brasil
dc.description.fil
Fil: Varela Junior, Antônio Sergio. Universidade Federal do Rio Grande; Brasil. Universidade Federal de Pelotas; Brasil
dc.description.fil
Fil: Corcini, Carine D.. Universidade Federal de Pelotas; Brasil
dc.description.fil
Fil: Costa, Patrícia G.. Universidade Federal do Rio Grande; Brasil
dc.description.fil
Fil: Bianchini, Adalto. Universidade Federal do Rio Grande; Brasil
dc.description.fil
Fil: Somoza, Gustavo Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús). Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús); Argentina
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Fil: Robaldo, Ricardo B.. Universidade Federal de Pelotas; Brasil
dc.description.fil
Fil: Campos, Vinicius Farias. Universidade Federal de Pelotas; Brasil
dc.journal.title
Environmental Science and Pollution Research
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs11356-021-15239-w
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1007/s11356-021-15239-w
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