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dc.contributor.author
Karasov, William
dc.contributor.author
Caviedes Vidal, Enrique Juan Raul
dc.date.available
2021-07-22T20:12:24Z
dc.date.issued
2021-03
dc.identifier.citation
Karasov, William; Caviedes Vidal, Enrique Juan Raul; Adaptation of intestinal epithelial hydrolysis and absorption of dietary carbohydrate and protein in mammals and birds; Elsevier Science Inc.; Comparative Biochemistry and Physiology Part A: Molecular and Integrative Physiology; 253; 110860; 3-2021; 1-9
dc.identifier.issn
1095-6433
dc.identifier.uri
http://hdl.handle.net/11336/136710
dc.description.abstract
The small intestine of mammals and birds exhibits fascinating variation across taxa, body size, and life history features such as locomotion and diet. In the intestine's brush border membrane (BBM), hydrolases are more abundant than transporters in both mammals and birds, but there are differences among the groups in abundance of certain hydrolases and possibly in transporters. For example, mammals express two α-glucosidases, sucrase-isomaltase (SI) and maltase glucoamylase (MGAM), whereas songbirds we studied have only SI, and the chicken expresses SI plus another α-glucosidase that functions similarly to MGAM but is not a true ortholog. For intestinal absorption of sugars and amino acids, small fliers rely on a paracellular pathway to a greater extent than do nonflying mammals, which rely more on transporters. Possibly having evolved in fliers as compensation for lower intestinal nominal surface area (NSA), the fliers' reliance on paracellular absorption is supported by their greater villous surface enlargement that leads to more (per cm2 NSA) tight junctions and greater clearance of passively absorbed compounds. To match digestive capacity to nutrient load, a positive relationship is often observed between dietary intake of macronutrients and intestinal activity of the enzymes and transporters of their respective constituents. In enterocytes, rapid, fine-tuned adjustment to high dietary carbohydrate and protein involves rapid, specific correlated increase in activity and abundance of hydrolases and transporters in the BBM and increases in their mRNA.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science Inc.
dc.rights
info:eu-repo/semantics/embargoedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
AMINOPEPTIDASE-N
dc.subject
EVOLUTION
dc.subject
PROTEOMICS
dc.subject
RODENT
dc.subject
SGLT1
dc.subject.classification
Otras Ciencias Biológicas
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Adaptation of intestinal epithelial hydrolysis and absorption of dietary carbohydrate and protein in mammals and birds
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-04-28T20:36:50Z
dc.journal.volume
253
dc.journal.number
110860
dc.journal.pagination
1-9
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Karasov, William. University of Wisconsin; Estados Unidos
dc.description.fil
Fil: Caviedes Vidal, Enrique Juan Raul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina. University of Wisconsin; Estados Unidos
dc.journal.title
Comparative Biochemistry and Physiology Part A: Molecular and Integrative Physiology
dc.rights.embargoDate
2021-10-01
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S1095643320302130
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.cbpa.2020.110860
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