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Artículo

Effect of low dose metronomic therapy on MCF-7 tumor cells growth and angiogenesis. Role of muscarinic acetylcholine receptors

Salem, Agustina ReinaIcon ; Martinez Pulido, PaolaIcon ; Sanchez, F.; Sanchez, Y.; Español, Alejandro JavierIcon ; Sales, María ElenaIcon
Fecha de publicación: 07/2020
Editorial: Elsevier Science
Revista: International Immunopharmacology
ISSN: 1567-5769
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Medicina Básica

Resumen

The non-neuronal cholinergic system refers to the presence of acetylcholine, choline acetyltransferase, acetylcholinesterase and cholinergic receptors, nicotinic and muscarinic (mAChRs) expressed in non-neuronal cells. The presence of mAChRs has been detected in different type of tumor cells and they are linked with tumorigenesis. We had previously documented the expression of mAChRs in murine and human mammary adenocarcinomas and the absence of these receptors in normal mammary cells of the same origins. We also demonstrated that mAChRs are involved in breast cancer progression, pointing to a main role for mAChRs as oncogenic proteins. Since the long term treatment of breast cancer cells with the muscarinic agonist carbachol promoted cell death, here we investigated the ability of low doses of this agonist combined with paclitaxel (PX), a taxane usually administered to treat breast cancer, to inhibit the progression of human MCF-7 tumor cells. We demonstrated that PX plus carbachol reduced cell viability and tumor growth in vitro probably due to a down-regulation in cancer stem cells population and in the expression of ATP “binding cassette” G2 drug extrusion pump; also a reduction in malignant-induced angiogenesis was produced by the in vivo administration of the mentioned combination in a metronomic schedule to MCF-7 tumor-bearing NUDE mice. Our results confirm that mAChRs could be considered as therapeutic targets for metronomic therapy in breast cancer as well as the usefulness of a muscarinic agonist as repositioning drug in the treatment of this type of tumors.
Palabras clave: ABCG2 , ANGIOGENESIS , CD44+/CD24− CELLS , IN VITRO TUMOR GROWTH , MCF-7 BREAST TUMOR CELLS , METRONOMIC THERAPY , MUSCARINIC RECEPTORS
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/136683
URL: https://linkinghub.elsevier.com/retrieve/pii/S1567576920302095
DOI: http://dx.doi.org/10.1016/j.intimp.2020.106514
Colecciones
Articulos(CEFYBO)
Articulos de CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Citación
Salem, Agustina Reina; Martinez Pulido, Paola; Sanchez, F.; Sanchez, Y.; Español, Alejandro Javier; et al.; Effect of low dose metronomic therapy on MCF-7 tumor cells growth and angiogenesis. Role of muscarinic acetylcholine receptors; Elsevier Science; International Immunopharmacology; 84; 7-2020; 1-9
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