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Artículo

Effects of 5α-dihydrotestosterone on expression of genes related to steroidogenesis and spermatogenesis during the sex determination and differentiation periods of the pejerrey, Odontesthes bonariensis

González, AnelisaIcon ; Fernandino, Juan IgnacioIcon ; Somoza, Gustavo ManuelIcon
Fecha de publicación: 04/2015
Editorial: Elsevier Inc
Revista: Comparative Biochemistry And Physiology Part A: Molecular And Integrative Physiology
ISSN: 1095-6433
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Biología del Desarrollo

Resumen

Sex steroid hormones are important players in the control of sex differentiation by regulating gonadal development in teleosts. Although estrogens are clearly associated with the ovarian differentiation in teleosts, the effects of androgens on early gonadal development are still a matter of debate. Traditionally, 11-ketotestosterone (11-KT) is considered the major androgen in fish; however, 5α-dihydrotestosterone (5α-DHT), the most potent androgen in tetrapods, was recently found in fish testis and plasma, but its physiological role is still unknown. In this context, the expression of genes associated with steroidogenesis and spermatogenesis, body growth and sex differentiation were assessed in Odontesthes bonariensis larvae fed with food supplemented with two doses of 5α-DHT (0.1 and 10 μg/g of food) from hatching to 6 weeks of age. At the lowest dose, 5α-DHT treated larvae showed an estrogenic gene expression pattern, with low hsd11b2 and high cyp19a1a and er2 expression levels with no differences in sex ratio. At the highest dose, 5α-DHT produced a male-shifted sex ratio and the larvae exhibited a gene expression profile characteristic of an advancement of spermatogenesis, with inhibition of amh and stimulation of ndrg3. No differences were observed in somatic growth. These results suggest that in this species, 5α-DHT could have a role on sex differentiation and its effects can differ according to the dose.
Palabras clave: 5α-Dht , Pejerrey , Sexual Development , Spermatogenesis
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)
Identificadores
URI: http://hdl.handle.net/11336/13659
DOI: http://dx.doi.org/10.1016/j.cbpa.2014.12.003
URL: http://www.sciencedirect.com/science/article/pii/S1095643314002566
Colecciones
Articulos(CCT - LA PLATA)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - LA PLATA
Citación
González, Anelisa; Fernandino, Juan Ignacio; Somoza, Gustavo Manuel; Effects of 5α-dihydrotestosterone on expression of genes related to steroidogenesis and spermatogenesis during the sex determination and differentiation periods of the pejerrey, Odontesthes bonariensis; Elsevier Inc; Comparative Biochemistry And Physiology Part A: Molecular And Integrative Physiology; 182; 4-2015; 1-7
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