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Ciapponi, Agustín
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Bardach, Ariel Esteban
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Comandé, Daniel
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Berrueta, Mabel
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Argento, Fernando J.
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Rodriguez Cairoli, Federico
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Zamora, Natalia
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Santa María, Victoria
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Xiong, Xu
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Zaraa, Sabra
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Mazzoni, Agustina
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Buekens, Pierre
dc.date.available
2021-07-20T13:19:33Z
dc.date.issued
2021-06
dc.identifier.citation
Ciapponi, Agustín; Bardach, Ariel Esteban; Comandé, Daniel; Berrueta, Mabel; Argento, Fernando J.; et al.; COVID-19 and pregnancy: An umbrella review of clinical presentation, vertical transmission, and maternal and perinatal outcomes; Public Library of Science; Plos One; 16; 6 June; 6-2021; 1-27
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1932-6203
dc.identifier.uri
http://hdl.handle.net/11336/136491
dc.description.abstract
Background We conducted an overview of systematic reviews (SRs) summarizing the best evidence regarding the effect of COVID-19 on maternal and child health following Cochrane methods and PRISMA statement for reporting (PROSPERO-CRD42020208783). Methods We searched literature databases and COVID-19 research websites from January to October 2020. We selected relevant SRs reporting adequate search strategy, data synthesis, risk of bias assessment, and/or individual description of included studies describing COVID-19 and pregnancy outcomes. Pair of reviewers independently selected studies through COVIDENCE web-software, performed the data extraction, and assessed its quality through the AMSTAR-2 tool. Discrepancies were resolved by consensus. Each SR’s results were synthesized and for the most recent, relevant, comprehensive, and with the highest quality, by predefined criteria, we presented GRADE evidence tables. Results We included 66 SRs of observational studies out of 608 references retrieved and most (61/66) had "critically low" overall quality. We found a relatively low degree of primary study overlap across SRs. The most frequent COVID-19 clinical findings during pregnancy were fever (28–100%), mild respiratory symptoms (20–79%), raised C-reactive protein (28–96%), lymphopenia (34–80%), and pneumonia signs in diagnostic imaging (7–99%). The most frequent maternal outcomes were C-section (23–96%) and preterm delivery (14–64%). Most of their babies were asymptomatic (16–93%) or presented fever (0–50%), low birth weight (5–43%) or preterm delivery (2–69%). The odds ratio (OR) of receiving invasive ventilation for COVID-19 versus non-COVID-19 pregnant women was 1.88 (95% Confidence Interval [CI] 1.36–2.60) and the OR that their babies were admitted to neonatal intensive care unit was 3.13 (95%CI 2.05–4.78). The risk of congenital transmission or via breast milk was estimated to be low, but close contacts may carry risks. Conclusion This comprehensive overview supports that pregnant women with COVID-19 may be at increased risk of adverse pregnancy and birth outcomes and low risk of congenital transmission.
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application/pdf
dc.language.iso
eng
dc.publisher
Public Library of Science
dc.rights
info:eu-repo/semantics/openAccess
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https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
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COVID-19
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Neonates
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Pregnancy
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SARS CoV 2
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Medical risk factors
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Otras Ciencias de la Salud
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
COVID-19 and pregnancy: An umbrella review of clinical presentation, vertical transmission, and maternal and perinatal outcomes
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-07-19T16:08:22Z
dc.journal.volume
16
dc.journal.number
6 June
dc.journal.pagination
1-27
dc.journal.pais
Estados Unidos
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San Francisco
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Fil: Ciapponi, Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina. Instituto de Efectividad Clínica y Sanitaria; Argentina
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Fil: Bardach, Ariel Esteban. Instituto de Efectividad Clínica y Sanitaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
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Fil: Comandé, Daniel. Instituto de Efectividad Clínica y Sanitaria; Argentina
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Fil: Berrueta, Mabel. Instituto de Efectividad Clínica y Sanitaria; Argentina
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Fil: Argento, Fernando J.. Instituto de Efectividad Clínica y Sanitaria; Argentina
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Fil: Rodriguez Cairoli, Federico. Instituto de Efectividad Clínica y Sanitaria; Argentina
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Fil: Zamora, Natalia. Instituto de Efectividad Clínica y Sanitaria; Argentina
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Fil: Santa María, Victoria. Instituto de Efectividad Clínica y Sanitaria; Argentina
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Fil: Xiong, Xu. University of Tulane; Estados Unidos
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Fil: Zaraa, Sabra. University of Washington; Estados Unidos
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Fil: Mazzoni, Agustina. Instituto de Efectividad Clínica y Sanitaria; Argentina
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Fil: Buekens, Pierre. University of Tulane; Estados Unidos
dc.journal.title
Plos One
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info:eu-repo/semantics/altIdentifier/url/https://dx.plos.org/10.1371/journal.pone.0253974
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1371/journal.pone.0253974
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