Artículo
Effect of an intracerebroventricular injection of aggregated Beta-amyloid (1–42) on daily rhythms of oxidative stress parameters in the prefrontal cortex
Ledezma, Carina Leticia; Coria Lucero, Cinthia Daiana
; Delsouc, María Belén
; Casais, Marilina
; Della Vedova, Maria Cecilia
; Ramirez, Darío Alejandro
; Devia, Cristina Mabel; Delgado, Silvia Marcela; Navigatore Fonzo, Lorena Silvina
; Anzulovich Miranda, Ana Cecilia
Fecha de publicación:
15/03/2021
Editorial:
Elsevier
Revista:
Neuroscience
ISSN:
0306-4522
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Accumulation of amyloid peptides in the brain plays a key role in the pathogenesis of Alzheimer's disease (AD). Aggregated beta-amyloid (Aβ) peptide increases intracellular reactive oxygen species associated to a deficient antioxidant defense system. Prefrontal cortex plays a key role in memory and learning and is especially susceptible to oxidative stress. The objective of this work was to investigate the effects of an intracerebroventricular (i.c.v.) injection of Aβ (1–42) on 24 h patterns of oxidative stress parameters and antioxidant defenses in the rat prefrontal cortex. Four-month-old male Holtzman rats were divided into two groups defined as: control (CO) and Aβ-injected (Aβ). Rats were maintained under12 h-light:12 h-dark conditions and received water and food ad libitum. Tissues samples were isolated every 6 h during a 24 h period. Interestingly, we found that an i.c.v. injection of Aβ(1–42) increased lipid peroxidation, reduced total antioxidant capacity level, phase-shifted the daily peak of reduced glutathione, and had a differential effect on the oscillating catalase and glutathione peroxidase specific activity. Thus, elevated levels of Aβ aggregates-a pathogenic hallmark of AD, caused altered temporal patterns of the cellular redox state in prefrontal cortex rat. These findings might contribute, at least in part, to the understanding of the molecular and biochemical basis of redox changes caused by circadian rhythms alterations observed in AD patients.
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Articulos(IMIBIO-SL)
Articulos de INST. MULTIDICIPLINARIO DE INV. BIO. DE SAN LUIS
Articulos de INST. MULTIDICIPLINARIO DE INV. BIO. DE SAN LUIS
Citación
Ledezma, Carina Leticia; Coria Lucero, Cinthia Daiana; Delsouc, María Belén; Casais, Marilina; Della Vedova, Maria Cecilia; et al.; Effect of an intracerebroventricular injection of aggregated Beta-amyloid (1–42) on daily rhythms of oxidative stress parameters in the prefrontal cortex; Elsevier; Neuroscience; 458; 15-3-2021; 99-107
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