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dc.contributor.author
Ávila Portillo, Luz Mabel
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dc.contributor.author
Aristizabal, F.
dc.contributor.author
Perdomo, S.
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Riveros, A.
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Ospino, B.
dc.contributor.author
Avila, J. P.
dc.contributor.author
Butti, M.
dc.contributor.author
Abba, Martín Carlos
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dc.date.available
2021-07-17T01:54:07Z
dc.date.issued
2020-03-20
dc.identifier.citation
Ávila Portillo, Luz Mabel; Aristizabal, F.; Perdomo, S.; Riveros, A.; Ospino, B.; et al.; Comparative analysis of the biosimilar and innovative G-CSF modulated pathways on umbilical cord blood–derived mononuclear cells; SAGE Publications; Bioinformatics and Biology Insights; 14; 20-3-2020; 1-7
dc.identifier.issn
1177-9322
dc.identifier.uri
http://hdl.handle.net/11336/136376
dc.description.abstract
Biosimilars of granulocyte colony-stimulating factor (G-CSF) have been routinely introduced into clinical practice. However, not functional genomics characterization has been performed yet in comparison with the innovator G-CSF. This study aimed to evaluate the transcriptomic changes in an in vitro model of umbilical cord blood cells (UBC) exposed to G-CSF for the identification of their modulated pathways. Umbilical cord blood cells–derived mononuclear cells (MNCs) were treated with biosimilar and innovator G-CSF for further gene expression profiling analysis using a microarray-based platform. Comparative analysis of biosimilar and innovator G-CSF gene expression signatures allowed us to identify the most commonly modulated pathways by both drugs. In brief, we observed predominantly upmodulation of transcripts related to PI3K-Akt, NF-kappaB, and tumor necrosis factor (TNF) signaling pathways as well as transcripts related to negative regulation of apoptotic process among others. In addition, hematopoietic colony-forming cell assays corroborate the G-CSF phenotypic effects over UBC-derived MNCs. In conclusion, our study suggests that G-CSF impacts UBC-derived cells through the modulation of several signaling pathways associated with cell survival, migration, and proliferation. The concordance observed between biosimilar and innovator G-CSF emphasizes their similarity in regards to their specificity and biological responses.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
SAGE Publications
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.subject
BIOSIMILAR
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G-CSF
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INNOVATOR
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TRANSCRIPTOMICS
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UMBILICAL CORD BLOOD
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Bioquímica y Biología Molecular
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
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dc.title
Comparative analysis of the biosimilar and innovative G-CSF modulated pathways on umbilical cord blood–derived mononuclear cells
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-07-15T12:24:05Z
dc.identifier.eissn
1177-9322
dc.journal.volume
14
dc.journal.pagination
1-7
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Ávila Portillo, Luz Mabel. Universidad Nacional de Colombia; Colombia. Stem Medicina Regenerativa/CryoHoldco; Colombia. Hospital Militar Central. Unidad de Investigación; Colombia
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Fil: Aristizabal, F.. Universidad Nacional de Colombia; Colombia
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Fil: Perdomo, S.. Universidad El Bosque. Facultad de Odontología; Colombia
dc.description.fil
Fil: Riveros, A.. Stem Medicina Regenerativa/CryoHoldco; Colombia
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Fil: Ospino, B.. Stem Medicina Regenerativa/CryoHoldco; Colombia
dc.description.fil
Fil: Avila, J. P.. Stem Medicina Regenerativa/CryoHoldco; Colombia
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Fil: Butti, M.. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Inmunológicas Básicas y Aplicadas; Argentina. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas; Argentina
dc.description.fil
Fil: Abba, Martín Carlos. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Inmunológicas Básicas y Aplicadas; Argentina. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
dc.journal.title
Bioinformatics and Biology Insights
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1177/1177932220913307
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://journals.sagepub.com/doi/10.1177/1177932220913307
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