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dc.contributor.author
Garcia Rill, Edgar  
dc.contributor.author
Luster, Brennon  
dc.contributor.author
Mahaffey, Susan  
dc.contributor.author
Bisagno, Veronica  
dc.contributor.author
Urbano Suarez, Francisco Jose  
dc.date.available
2017-03-07T20:10:27Z  
dc.date.issued
2015-04  
dc.identifier.citation
Garcia Rill, Edgar; Luster, Brennon; Mahaffey, Susan; Bisagno, Veronica; Urbano Suarez, Francisco Jose; Pedunculopontine arousal system physiology – implications for insomnia; Elsevier Science; Sleep Science; 8; 2; 4-2015; 92-99  
dc.identifier.issn
1984-0063  
dc.identifier.uri
http://hdl.handle.net/11336/13603  
dc.description.abstract
We consider insomnia a disorder of waking rather than a disorder of sleep. This review examines the role of the reticular activating system, especially the pedunculopontine nucleus, in the symptoms of insomnia, mainly representing an overactive waking drive. We determined that high frequency activity during waking and REM sleep is controlled by two different intracellular pathways and channel types in PPN cells. We found three different PPN cell types that have one or both channels and may be active during waking only, REM sleep only, or both. These discoveries point to a specific mechanism and novel therapeutic avenues for insomnia.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier Science  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/  
dc.subject
Calcium Channels  
dc.subject
Gamma Band Activity  
dc.subject
Neuronal Calcium Sensor Protein  
dc.subject
N-Type Calcium Channel  
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P/Q-Type Calcium Channel  
dc.subject.classification
Neurociencias  
dc.subject.classification
Medicina Básica  
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Pedunculopontine arousal system physiology – implications for insomnia  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2017-03-07T15:20:31Z  
dc.journal.volume
8  
dc.journal.number
2  
dc.journal.pagination
92-99  
dc.journal.pais
Países Bajos  
dc.journal.ciudad
Ámsterdam  
dc.description.fil
Fil: Garcia Rill, Edgar. University Of Arkansas For Medical Sciences; Estados Unidos  
dc.description.fil
Fil: Luster, Brennon. University Of Arkansas For Medical Sciences; Estados Unidos  
dc.description.fil
Fil: Mahaffey, Susan. University Of Arkansas For Medical Sciences; Estados Unidos  
dc.description.fil
Fil: Bisagno, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas (i); Argentina  
dc.description.fil
Fil: Urbano Suarez, Francisco Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina  
dc.journal.title
Sleep Science  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S198400631500036X  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.slsci.2015.06.002