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dc.contributor.author
Slachevsky, Andrea
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Forno, Gonzalo
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Barraza, Paulo
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Mioshi, Eneida
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Delgado, Carolina
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Lillo, Patricia
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Henriquez, Fernando
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Bravo, Eduardo
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Farias, Mauricio
dc.contributor.author
Muñoz Neira, Carlos
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Ibañez, Agustin Mariano
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Parra, Mario A.
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Hornberger, Michael
dc.date.available
2021-07-13T17:40:07Z
dc.date.issued
2019-06
dc.identifier.citation
Slachevsky, Andrea; Forno, Gonzalo; Barraza, Paulo; Mioshi, Eneida; Delgado, Carolina; et al.; Mapping the neuroanatomy of functional decline in Alzheimer’s disease from basic to advanced activities of daily living; Dr. Dietrich Steinkopff Verlag; Journal of Neurology; 266; 6; 6-2019; 1310-1322
dc.identifier.issn
0340-5354
dc.identifier.uri
http://hdl.handle.net/11336/136001
dc.description.abstract
Background: Impairments in activities of daily living (ADL) are a criterion for Alzheimer’s disease (AD) dementia. However, ADL gradually decline in AD, impacting on advanced (a-ADL, complex interpersonal or social functioning), instrumental (IADL, maintaining life in community), and finally basic functions (BADL, activities related to physiological and self-maintenance needs). Information and communication technologies (ICT) have become an increasingly important aspect of daily functioning. Yet, the links of ADL, ICT, and neuropathology of AD dementia are poorly understood. Such knowledge is critical as it can provide biomarker evidence of functional decline in AD. Methods: ADL were evaluated with the Technology–Activities of Daily Living Questionnaire (T-ADLQ) in 33 patients with AD and 30 controls. ADL were divided in BADL, IADL, and a-ADL. The three domain subscores were covaried against gray matter atrophy via voxel-based morphometry. Results: Our results showed that three domain subscores of ADL correlate with several brain structures, with a varying degree of overlap between them. BADL score correlated mostly with frontal atrophy, IADL with more widespread frontal, temporal and occipital atrophy and a-ADL with occipital and temporal atrophy. Finally, ICT subscale was associated with atrophy in the precuneus. Conclusions: The association between ADL domains and neurodegeneration in AD follows a traceable neuropathological pathway which involves different neural networks. This the first evidence of ADL phenotypes in AD characterised by specific patterns of functional decline and well-defined neuropathological changes. The identification of such phenotypes can yield functional biomarkers for dementias such as AD.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Dr. Dietrich Steinkopff Verlag
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ACTIVITIES OF DAILY LIVING
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ALZHEIMER’S DISEASE
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FUNCTIONAL IMPAIRMENT
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TECHNOLOGY–ACTIVITIES OF DAILY LIVING QUESTIONNAIRE
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Neurociencias
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Mapping the neuroanatomy of functional decline in Alzheimer’s disease from basic to advanced activities of daily living
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-11-20T17:29:17Z
dc.journal.volume
266
dc.journal.number
6
dc.journal.pagination
1310-1322
dc.journal.pais
Alemania
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dc.journal.ciudad
Heidelberg
dc.description.fil
Fil: Slachevsky, Andrea. Universidad de Chile; Chile. Clínica Alemana-Universidad del Desarrollo. Departamento de Medicina. Servicio de Neurología; Chile
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Fil: Forno, Gonzalo. Universidad de Chile; Chile
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Fil: Barraza, Paulo. Universidad de Chile; Chile
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Fil: Mioshi, Eneida. University of East Anglia; Reino Unido
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Fil: Delgado, Carolina. Universidad de Chile; Chile
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Fil: Lillo, Patricia. Universidad de Chile; Chile
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Fil: Henriquez, Fernando. Universidad de Chile; Chile
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Fil: Bravo, Eduardo. Institute of Neurosurgery Asenjo; Chile
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Fil: Farias, Mauricio. Institute of Neurosurgery Asenjo; Chile
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Fil: Muñoz Neira, Carlos. Universidad de Chile; Chile
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Fil: Ibañez, Agustin Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina. Universidad Autónoma del Caribe; Colombia. Universidad Adolfo Ibáñez; Chile. Australian Research Council (acr); Australia
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Fil: Parra, Mario A.. Universidad Autónoma del Caribe; Colombia. University of Strathclyde; Reino Unido
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Fil: Hornberger, Michael. University of East Anglia; Reino Unido. Norfolk and Suffolk Foundation Trust; Reino Unido
dc.journal.title
Journal of Neurology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s00415-019-09260-w
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00415-019-09260-w
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