Artículo
Diminished production of T helper 1 cytokines correlates with T cell unresponsiveness to Brucella cytoplasmic proteins in chronic human brucellosis
Giambartolomei, Guillermo Hernan
; Delpino, María Victoria
; Cahanovich, Mariela E.; Wallach, Jorge Carlos; Baldi, Pablo Cesar
; Velikovsky, Carlos A.; Fossati, Carlos Alberto
Fecha de publicación:
12/2002
Editorial:
University of Chicago Press
Revista:
Journal Of Infectious Diseases
ISSN:
0022-1899
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
This study evaluated the cellular immune response against Brucella species cytoplasmic protein (CP) in peripheral blood mononuclear cells (PBMC) of 25 patients with brucellosis. In vitro proliferation and cytokine gene expression and production were investigated. PBMC from 14 patients proliferated in response to CP (responder patients [RPs]) and cells from 11 patients did not (nonresponder patients [NRPs]). CP-specific interleukin (IL)-2 and interferon-γ were significantly induced in PBMC from RPs, compared with cells from NRPs. No significant differences were found in the production of IL-10 between the 2 groups. CP did not induce IL-4 production. A close relationship was observed between the clinical status of the patients and the T cell response against CP. Patient with acute infections responded to CP and induced production of T helper 1 (Th1) cytokines, whereas chronically infected patients did not. Diminished production of Th1 cytokines may contribute to T cell unresponsiveness in chronic human brucellosis.
Palabras clave:
Brucellosis
,
Proteins
,
Th1
,
Chronic disease
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Colecciones
Articulos(IDEHU)
Articulos de INST.DE EST.DE LA INMUNIDAD HUMORAL PROF.R.A.MARGNI
Articulos de INST.DE EST.DE LA INMUNIDAD HUMORAL PROF.R.A.MARGNI
Articulos(INIGEM)
Articulos de INSTITUTO DE INMUNOLOGIA, GENETICA Y METABOLISMO
Articulos de INSTITUTO DE INMUNOLOGIA, GENETICA Y METABOLISMO
Citación
Giambartolomei, Guillermo Hernan; Delpino, María Victoria; Cahanovich, Mariela E.; Wallach, Jorge Carlos; Baldi, Pablo Cesar; et al.; Diminished production of T helper 1 cytokines correlates with T cell unresponsiveness to Brucella cytoplasmic proteins in chronic human brucellosis; University of Chicago Press; Journal Of Infectious Diseases; 186; 2; 12-2002; 252-259
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