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dc.contributor.author
Lajmanovich, Rafael Carlos
dc.contributor.author
Peltzer, Paola
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Attademo, Andres Maximiliano
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Martinuzzi, Candela Soledad
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Simoniello, María F.
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Colussi, Carlina Leila
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Cuzziol Boccioni, Ana Paula
dc.contributor.author
Sigrist, Mirna
dc.date.available
2021-07-13T16:00:05Z
dc.date.issued
2019-10
dc.identifier.citation
Lajmanovich, Rafael Carlos; Peltzer, Paola; Attademo, Andres Maximiliano; Martinuzzi, Candela Soledad; Simoniello, María F.; et al.; First evaluation of novel potential synergistic effects of glyphosate and arsenic mixture on Rhinella arenarum (Anura: Bufonidae) tadpoles; Elsevier; Heliyon; 5; 10; 10-2019; 1-11
dc.identifier.issn
2405-8440
dc.identifier.uri
http://hdl.handle.net/11336/135978
dc.description.abstract
The toxicity of glyphosate-based herbicide (GBH) and arsenite (As(III)) as individual toxicants and in mixture(50:50 v/v, GBH-As(III)) was determined in Rhinella arenarum tadpoles during acute (48 h) and chronic assays (22days). In both types of assays, the levels of enzymatic activity [Acetylcholinesterase (AChE), Carboxylesterase(CbE), and Glutathione S-transferase (GST)] and the levels of thyroid hormones (triiodothyronine; T3 andthyroxine; T4) were examined. Additionally, the mitotic index (MI) of red blood cells (RBCs) and DNA damageindex were calculated for the chronic assay. The results showed that the LC50 values at 48 h were 45.95 mg/L forGBH, 37.32 mg/L for As(III), and 30.31 mg/L for GBH-As(III) (with similar NOEC ¼ 10 mg/L and LOEC ¼ 20 mg/L between the three treatments). In the acute assay, Marking´s additive index (S ¼ 2.72) indicated synergistictoxicity for GBH-As(III). In larvae treated with GBH and As(III) at the NOEC-48h (10 mg/L), AChE activityincreased by 36.25% and 33.05% respectively, CbE activity increased by 22.25% and 39.05 % respectively, andGST activity increased by 46.75% with the individual treatment with GBH and by 131.65 % with the GBH-As(III)mixture. Larvae exposed to the GBH-As(III) mixture also showed increased levels of T4 (25.67 %). In the chronicassay at NOEC-48h/8 (1.25 mg/L), As(III) and GBH-As(III) inhibited AChE activity (by 39.46 % and 35.65%,respectively), but did not alter CbE activity. In addition, As(III) highly increased (93.7 %) GST activity. GBHAs(III)increased T3 (97.34%) and T4 (540.93%) levels. Finally, GBH-As(III) increased the MI of RBCs andDNA damage. This study demonstrated strong synergistic toxicity of the GBH-As(III) mixture, negatively alteringantioxidant systems and thyroid hormone levels, with consequences on RBC proliferation and DNA damage intreated R. arenarum tadpoles.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
AMPHIBIANS
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ARSENITE
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BIOMARKERS
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DNA
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ENVIRONMENTAL SCIENCE
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GLYPHOSATE
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TOXICOLOGY
dc.subject.classification
Otras Ciencias Naturales y Exactas
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Otras Ciencias Naturales y Exactas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
First evaluation of novel potential synergistic effects of glyphosate and arsenic mixture on Rhinella arenarum (Anura: Bufonidae) tadpoles
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-11-27T18:44:23Z
dc.journal.volume
5
dc.journal.number
10
dc.journal.pagination
1-11
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Lajmanovich, Rafael Carlos. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Laboratorio de Saneamiento Ambiental. Cátedra de Ecotoxicología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
dc.description.fil
Fil: Peltzer, Paola. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Laboratorio de Saneamiento Ambiental. Cátedra de Ecotoxicología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
dc.description.fil
Fil: Attademo, Andres Maximiliano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Laboratorio de Saneamiento Ambiental. Cátedra de Ecotoxicología; Argentina
dc.description.fil
Fil: Martinuzzi, Candela Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Laboratorio de Saneamiento Ambiental. Cátedra de Ecotoxicología; Argentina
dc.description.fil
Fil: Simoniello, María F.. Universidad Nacional del Litoral; Argentina
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Fil: Colussi, Carlina Leila. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Laboratorio de Saneamiento Ambiental. Cátedra de Ecotoxicología; Argentina
dc.description.fil
Fil: Cuzziol Boccioni, Ana Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Laboratorio de Saneamiento Ambiental. Cátedra de Ecotoxicología; Argentina
dc.description.fil
Fil: Sigrist, Mirna. Universidad Nacional del Litoral; Argentina
dc.journal.title
Heliyon
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.heliyon.2019.e02601
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.cell.com/heliyon/fulltext/S2405-8440(19)36261-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2405844019362619%3Fshowall%3Dtrue
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