Artículo
Glial-neuronal ensembles: partners in drug addiction-associated synaptic plasticity
Fecha de publicación:
09/2014
Editorial:
Frontiers
Revista:
Frontiers in Pharmacology
e-ISSN:
1663-9812
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Drug addiction is manifested by a compulsive drive to take licit or illicit substances despite repeated severe adverse consequences (Volkow et al., 2012). Addiction is also accompanied by a vicious cycle of binges, abstinence, and relapses. Almost all drugs of abuse trigger euphoric feelings consequent to a rapid increase of dopamine levels in the mesolimbic system. Even after long periods of abstinence, addicts remain vulnerable to drug craving and/or relapses that can be triggered by stimuli previously associated with drugs (Koob and Volkow, 2010). These features of addiction suggest that drugs might cause a form of persistent neuroplasticity that is acutely responsive to environmental stimuli, with consequent compulsive drug-seeking and taking behaviors.
Palabras clave:
Synaptic Plasticity
,
Drug Abuse
,
Microglia
,
Astroglia
,
Oligodendroglia
,
Inflammation
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Identificadores
Colecciones
Articulos(ININFA)
Articulos de INST.DE INVEST.FARMACOLOGICAS (I)
Articulos de INST.DE INVEST.FARMACOLOGICAS (I)
Citación
Cadet, Jean Lud; Bisagno, Veronica; Glial-neuronal ensembles: partners in drug addiction-associated synaptic plasticity; Frontiers; Frontiers in Pharmacology; 5; 204; 9-2014; 1-5
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