Artículo
PPAR activation as a regulator of lipid metabolism, nitric oxide production and lipid peroxidation in the placenta from type 2 diabetic patients.
Capobianco, Evangelina Lorena
; Martinez, Nora Alicia
; Fornes, Daiana
; Higa, Romina Daniela
; Di Marco, Ingrid; Basualdo, María Natalia; Faingold, María Cristina; Jawerbaum, Alicia Sandra
Fecha de publicación:
09/2013
Editorial:
Elsevier Ireland
Revista:
Molecular And Cellular Endocrinology
ISSN:
0303-7207
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Peroxisome proliferator activated receptors (PPARs) are ligand activated transcription factors with crucial functions in lipid homeostasis, anti-inflammatory processes and placental development. Maternal diabetes induces a pro-inflammatory environment and alters placental development. We investigated whether PPARs regulate lipid metabolism and nitric oxide (NO) production in placental explants from healthy and type 2 diabetic (DM2) patients. We found decreased PPARα and PPARγ concentrations, no changes in PPARδ concentrations, and increased lipids, lipoperoxides and NO production in placentas from DM2 patients. PPARα agonists reduced placental concentrations of triglycerides and both PPARα and PPARδ agonists reduced concentrations of phospholipids, cholesteryl esters and cholesterol. PPARγ agonists increased lipid concentrations in placentas from DM2 patients and more markedly in placentas from healthy patients. Endogenous ligands for the three PPAR isotypes reduced NO production and lipoperoxidation in placentas from DM2 patients. We conclude that PPARs play a role in placental NO and lipid homeostasis and can regulate NO production, lipid concentrations and lipoperoxidation in placentas from DM2 patients.
Palabras clave:
Diabetes in Pregnancy
,
Placenta
,
Lipid Metabolism
,
Ppars
,
Nitric Oxide
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Articulos(CEFYBO)
Articulos de CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Articulos de CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Citación
Capobianco, Evangelina Lorena; Martinez, Nora Alicia; Fornes, Daiana; Higa, Romina Daniela; Di Marco, Ingrid; et al.; PPAR activation as a regulator of lipid metabolism, nitric oxide production and lipid peroxidation in the placenta from type 2 diabetic patients.; Elsevier Ireland; Molecular And Cellular Endocrinology; 377; 1-2; 9-2013; 7-15
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