Artículo
Exploiting cyanine dye J-aggregates/monomer equilibrium in hydrophobic protein pockets for efficient multi-step phototherapy: An innovative concept for smart nanotheranostics
Picchio, Matías Luis
; Bergueiro, Julian; Wedepohl, Stefanie; Minari, Roque Javier
; Alvarez Igarzabal, Cecilia Ines
; Gugliotta, Luis Marcelino
; Cuggino, Julio César
; Calderón, Marcelo
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Fecha de publicación:
04/2021
Editorial:
Royal Society of Chemistry
Revista:
Nanoscale
ISSN:
2040-3364
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
After several decades of development in the field of near-infrared (NIR) dyes for photothermal therapy (PTT), indocyanine green (ICG) still remains the only FDA-approved NIR contrast agent. However, upon NIR light irradiation ICG can react with molecular oxygen to form reactive oxygen species and degrade the ICG core, losing the convenient dye properties. In this work, we introduce a new approach for expanding the application of ICG in nanotheranostics, which relies on the confinement of self-organized J-type aggregates in hydrophobic protein domains acting as monomer depots. Upon the fast photobleaching, while the dye is irradiated, this strategy permits the equilibrium-driven monomer replacement after each irradiation cycle that radically increases the systems' effectivity and applicability. Gadolinium-doped casein micelles were designed to prove this novel concept at the same time as endowing the nanosystems with further magnetic resonance imaging (MRI) ability for dual-modal imaging-guided PTT. By teaching a new trick to a very old dog, the clinical prospect of ICG will undoubtedly be boosted laying the foundation for novel therapeutics. It is anticipated that future research could be expanded to other relevant J-aggregates-forming cyanine dyes or nanocrystal formulations of poorly water-soluble photosensitizers.
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Articulos(INTEC)
Articulos de INST.DE DES.TECNOL.PARA LA IND.QUIMICA (I)
Articulos de INST.DE DES.TECNOL.PARA LA IND.QUIMICA (I)
Articulos(IPQA)
Articulos deINSTITUTO DE INVESTIGACION Y DESARROLLO EN INGENIERIA DE PROCESOS Y QUIMICA APLICADA
Articulos deINSTITUTO DE INVESTIGACION Y DESARROLLO EN INGENIERIA DE PROCESOS Y QUIMICA APLICADA
Citación
Picchio, Matías Luis; Bergueiro, Julian; Wedepohl, Stefanie; Minari, Roque Javier; Alvarez Igarzabal, Cecilia Ines; et al.; Exploiting cyanine dye J-aggregates/monomer equilibrium in hydrophobic protein pockets for efficient multi-step phototherapy: An innovative concept for smart nanotheranostics; Royal Society of Chemistry; Nanoscale; 13; 19; 4-2021; 8909-8921
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