Artículo
Mucoadhesive and responsive nanogels as carriers for sustainable delivery of timolol for glaucoma therapy
Cuggino, Julio César
; Tartara, Luis Ignacio
; Gugliotta, Luis Marcelino
; Palma, Santiago Daniel
; Alvarez Igarzabal, Cecilia Ines
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Fecha de publicación:
01/2021
Editorial:
Elsevier Science
Revista:
Materials Science and Engineering: C
ISSN:
0928-4931
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Topical administration to the eye for the treatment of glaucoma is a convenient route because it increases the patient comfort. Timolol can efficiently diminish the intraocular pressure (IOP) of the eye; however the topical application as a solution of timolol maleate (TM) has poor therapeutic index and presents severe side effects. The encapsulation of timolol in nanomaterials has appeared as a technology to increase its residence time in the eye thus achieving a sustained release and consequently diminishing the doses of this drug and their number. The preparation of nanogels (NGs) based on N-isopropylacrylamide (NIPA) and acrylic acid (AAc), easily synthesized by precipitation/dispersion free radical polymerization, is reported in this paper. Such NGs presented excellent dispersability in eye simulated fluid and ideal size for topical application. NGs can load efficiently timolol through ionic interaction, and the in vitro release showed that NGs deliver timolol in a sustained manner. In vivo sustained efficacy of the NGs-timolol nanoformulations was demonstrated in rabbit´s glaucoma model, in which the IOP could be diminished and maintained constant for 48 h with only one application. Overall, the synthesized NGs in combination with timolol have potential as drug delivery system for glaucoma therapy.
Palabras clave:
DRUG DELIVERY
,
GLAUCOMA THERAPY
,
IONIC COMPLEXES
,
NANOGELS
,
TIMOLOL
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Colecciones
Articulos(INTEC)
Articulos de INST.DE DES.TECNOL.PARA LA IND.QUIMICA (I)
Articulos de INST.DE DES.TECNOL.PARA LA IND.QUIMICA (I)
Articulos(UNITEFA)
Articulos de UNIDAD DE INVESTIGACION Y DESARROLLO EN TECNOLOGIA FARMACEUTICA
Articulos de UNIDAD DE INVESTIGACION Y DESARROLLO EN TECNOLOGIA FARMACEUTICA
Citación
Cuggino, Julio César; Tartara, Luis Ignacio; Gugliotta, Luis Marcelino; Palma, Santiago Daniel; Alvarez Igarzabal, Cecilia Ines; Mucoadhesive and responsive nanogels as carriers for sustainable delivery of timolol for glaucoma therapy; Elsevier Science; Materials Science and Engineering: C; 118; 1-2021; 1-9
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