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dc.contributor.author
Mendizabal, Manuel
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Piñero, Federico
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Ridruejo, Ezequiel
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Anders, Margarita
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Silveyra, María Dolores
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Torre, Aldo
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Montes, Pedro
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Urzúa, Alvaro
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Pages, Josefina
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Toro, Luis G.
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Díaz, Javier
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Gonzalez Ballerga, Esteban
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Miranda Zazueta, Godolfino
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Peralta, Mirta
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Gutiérrez, Isabel
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Michelato, Douglas
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Venturelli, Maria Grazia
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Varón, Adriana
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Vera Pozo, Emilia
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Tagle, Martín
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García, Matías
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Tassara, Alfredo
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Brutti, Julia
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Ruiz García, Sandro
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Bustios, Carla
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Escajadillo, Nataly
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Macias, Yuridia
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Higuera de la Tijera, Fátima
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Gómez, Andrés J.
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Dominguez, Alejandra
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Castillo Barradas, Mauricio
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Contreras, Fernando
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Scarpin, Aldana
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Schinoni, Maria Isabel
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Toledo, Claudio
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Girala, Marcos
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Mainardi, Victoria
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Sanchez, Abel
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Bessone, Fernando
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Rubinstein, Fernando Adrian
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Silva, Marcelo Oscar
dc.date.available
2021-07-07T16:09:23Z
dc.date.issued
2021-03
dc.identifier.citation
Mendizabal, Manuel; Piñero, Federico; Ridruejo, Ezequiel; Anders, Margarita; Silveyra, María Dolores; et al.; Prospective Latin American cohort evaluating outcomes of patients with COVID-19 and abnormal liver tests on admission; Mexican Association of Hepatology; Annals of Hepatology; 21; 3-2021; 1-8
dc.identifier.issn
1665-2681
dc.identifier.uri
http://hdl.handle.net/11336/135658
dc.description.abstract
Introduction & objectives: The independent effect of liver biochemistries as a prognostic factor in patients with COVID-19 has not been completely addressed. We aimed to evaluate the prognostic value of abnormal liver tests on admission of hospitalized patients with COVID-19. Materials & methods: We performed a prospective cohort study including 1611 hospitalized patients with confirmed SARS-CoV-2 infection from April 15, 2020 through July 31, 2020 in 38 different Hospitals from 11 Latin American countries. We registered clinical and laboratory parameters, including liver function tests, on admission and during hospitalization. All patients were followed until discharge or death. We fit multivariable logistic regression models, further post-estimation effect through margins and inverse probability weighting. Results: Overall, 57.8% of the patients were male with a mean age of 52.3 years, 8.5% had chronic liver disease and 3.4% had cirrhosis. Abnormal liver tests on admission were present on 45.2% (CI 42.7–47.7) of the cohort (n = 726). Overall, 15.1% (CI 13.4–16.9) of patients died (n = 244). Patients with abnormal liver tests on admission presented higher mortality 18.7% (CI 15.9–21.7), compared to those with normal liver biochemistries 12.2% (CI 10.1–14.6); P < .0001). After excluding patients with history of chronic liver disease, abnormal liver tests on admission were independently associated with death [OR 1.5 (CI 1.1–2.0); P = 0.01], and severe COVID-19 (2.6 [2.0–3.3], P < .0001), both adjusted by age, gender, diabetes, pneumonia and body mass index >30. Conclusions: The presence of abnormal liver tests on admission is independently associated with mortality and severe COVID-19 in hospitalized patients with COVID-19 infection and may be used as surrogate marker of inflammation.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Mexican Association of Hepatology
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
CORONAVIRUS
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DEATH
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HEPATITIS
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PANDEMIC
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SARS-COV-2
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COVID-19
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Otras Ciencias de la Salud
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Prospective Latin American cohort evaluating outcomes of patients with COVID-19 and abnormal liver tests on admission
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-07-07T15:16:04Z
dc.journal.volume
21
dc.journal.pagination
1-8
dc.journal.pais
México
dc.description.fil
Fil: Mendizabal, Manuel. Universidad Austral. Hospital Universitario Austral; Argentina
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Fil: Piñero, Federico. Universidad Austral. Hospital Universitario Austral; Argentina
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Fil: Ridruejo, Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; Argentina
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Fil: Anders, Margarita. Hospital Aleman; Argentina
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Fil: Silveyra, María Dolores. Sanatorio Anchorena; Argentina
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Fil: Torre, Aldo. Centro Médico ABC; México
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Fil: Montes, Pedro. Hospital Nacional Daniel A. Carrión; Perú
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Fil: Urzúa, Alvaro. Hospital Clínico de la Universidad de Chile; Chile
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Fil: Pages, Josefina. Universidad Austral. Hospital Universitario Austral; Argentina
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Fil: Toro, Luis G.. Hospitales de San Vicente Fundación de Medellín y Rionegro; Colombia
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Fil: Díaz, Javier. Hospital Nacional Edgardo Rebagliati Martins; Perú
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Fil: Gonzalez Ballerga, Esteban. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
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Fil: Miranda Zazueta, Godolfino. Instituto Nacional de Ciencias Médicas y Nutrición; México
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Fil: Peralta, Mirta. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; Argentina
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Fil: Gutiérrez, Isabel. Centro Médico ABC; México
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Fil: Michelato, Douglas. Hospital Especializado en Enfermedades Infecciosas Instituto Couto Maia; Brasil
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Fil: Venturelli, Maria Grazia. Hospital Nacional Guillermo Almenara Irigoyen; Perú
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Fil: Varón, Adriana. Fundación Cardio-Infantil; Colombia
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Fil: Vera Pozo, Emilia. Hospital Regional Dr. Teodoro Maldonado Carbo; Ecuador
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Fil: Tagle, Martín. Clínica Anglo-Americana; Perú
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Fil: García, Matías. Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno"; Argentina
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Fil: Tassara, Alfredo. Hospital Aleman; Argentina
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Fil: Brutti, Julia. Sanatorio Anchorena; Argentina
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Fil: Ruiz García, Sandro. Hospital de Víctor Lazarte Echegaray; Perú
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Fil: Bustios, Carla. Clínica Delgado; Perú
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Fil: Escajadillo, Nataly. Hospital Nacional Almanzor Aguinaga Asenjo; Perú
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Fil: Macias, Yuridia. No especifíca;
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Fil: Higuera de la Tijera, Fátima. Hospital General de México “Dr. Eduardo Liceaga"; México
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Fil: Gómez, Andrés J.. Hospital Universitario Fundación Santa Fé de Bogotá; Colombia
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Fil: Dominguez, Alejandra. Hospital Padre Hurtado; Chile
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Fil: Castillo Barradas, Mauricio. Hospital de Especialidades del Centro Médico Nacional La Raza; México
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Fil: Contreras, Fernando. No especifíca;
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Fil: Scarpin, Aldana. Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno"; Argentina
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Fil: Schinoni, Maria Isabel. Hospital Alianza; Brasil
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Fil: Toledo, Claudio. Universidad Austral de Chile; Chile
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Fil: Girala, Marcos. Universidad Nacional de Asunción; Paraguay
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Fil: Mainardi, Victoria. Hospital Central De las Fuerzas Armadas; Uruguay
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Fil: Sanchez, Abel. Hospital Roosevelt; Guatemala
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Fil: Bessone, Fernando. Provincia de Santa Fe. Ministerio de Salud y Medio Ambiente - Rosario. Hospital Provincial del Centenario; Argentina
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Fil: Rubinstein, Fernando Adrian. Instituto de Efectividad Clínica y Sanitaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
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Fil: Silva, Marcelo Oscar. Universidad Austral. Hospital Universitario Austral; Argentina
dc.journal.title
Annals of Hepatology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1665268120302234?via%3Dihub
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.aohep.2020.100298
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