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dc.contributor.author
Hare, Jonathan
dc.contributor.author
Morrison, David
dc.contributor.author
Nielsen, Morten
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dc.date.available
2021-07-07T01:39:33Z
dc.date.issued
2021-02-19
dc.identifier.citation
Hare, Jonathan; Morrison, David; Nielsen, Morten; Sampling SARS-CoV-2 Proteomes for Predicted CD8 T-Cell Epitopes as a Tool for Understanding Immunogenic Breadth and Rational Vaccine Design; Frontiers in Bioscience; Frontiers in Bioinformatics; 1; 622992; 19-2-2021; 1-5
dc.identifier.uri
http://hdl.handle.net/11336/135604
dc.description.abstract
Predictive models for vaccine design have become a powerful and necessary resource for the expeditiousness design of vaccines to combat the ongoing SARS-CoV-2 global pandemic. Here we use the power of these predicted models to assess the sequence diversity of circulating SARS-CoV-2 proteomes in the context of an individual?s CD8 T-cell immune repertoire to identify potential. defined regions of immunogenicity. Using this approach of expedited and rational CD8 T-cell vaccine design, it may be possible to develop a therapeutic vaccine candidate with the potential for both global and local coverage.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Frontiers in Bioscience
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Sars-Cov-2
dc.subject
Epitopes
dc.subject
T cell
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COVID-19
dc.subject.classification
Otras Ciencias de la Salud
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dc.subject.classification
Ciencias de la Salud
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Sampling SARS-CoV-2 Proteomes for Predicted CD8 T-Cell Epitopes as a Tool for Understanding Immunogenic Breadth and Rational Vaccine Design
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-07-05T18:15:55Z
dc.identifier.eissn
2673-7647
dc.journal.volume
1
dc.journal.number
622992
dc.journal.pagination
1-5
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Hare, Jonathan. International AIDS Vaccine Initiative; Estados Unidos
dc.description.fil
Fil: Morrison, David. Bitefirst; Reino Unido
dc.description.fil
Fil: Nielsen, Morten. Technical University of Denmark; Dinamarca. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Frontiers in Bioinformatics
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fbinf.2021.622992/full
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3389/fbinf.2021.622992
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