Evento

Carvedilol and its non b-blocking analog VK-II-86 prevent digitalis-induced Ca2+ waves in cardiac myocyte

Gonano, Luis AlbertoIcon ; Sepúlveda, Marisa NoemíIcon ; Tottef, Tamara; Backs, Tom G.; Chen, S. R. Wayne; Morell, MalenaIcon ; Vila Petroff Martin
Tipo del evento: Congreso
Nombre del evento: 2016 ISHR World Congress Annual Meeting
Fecha del evento: 18/04/2016
Institución Organizadora: International Society for Heart Research;
Título de la revista: Journal of Molecular and Cellular Cardiology
Editorial: Academic Press Ltd - Elsevier Science Ltd
ISSN: 0022-2828
Idioma: Inglés
Clasificación temática:

Resumen

Cardiotonic glycosides inhibit the sarcolemmal Na+/ K+-ATPase and cause an increase in intracellular Na+, which reduces Ca++ extrusion through the Na+/Ca++ exchanger. The result is an increase in sarcoplasmic reticulum (SR) Ca++ load and cardiac contractility. However, these compounds have associated arrhythmic effects due to the occurrence of spontaneous SR Ca++ waves as a result of SR Ca++ overload and CaMKII-dependent phosphorylation of RyR2...
Palabras clave: CARVEDILOL , VK-II-86 , DIGITALIS , CARDIAC MYOCYTE
 
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Licencia
info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/135564
URL: https://www.sciencedirect.com/science/article/abs/pii/S0022282816302176
DOI: https://doi.org/10.1016/j.yjmcc.2016.06.065
Colecciones
Eventos(CIC)
Eventos de CENTRO DE INVEST.CARDIOVASCULARES (I)
Citación
Carvedilol and its non b-blocking analog VK-II-86 prevent digitalis-induced Ca2+ waves in cardiac myocyte; 2016 ISHR World Congress Annual Meeting; Buenos Aires; Argentina; 2016; 54-54
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