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Artículo

Efficacy of topical Miltefosine formulations in an experimental model of cutaneous leishmaniasis

Peralta, Maria FlorenciaIcon ; Usseglio, Nadina AiméIcon ; Bracamonte, María EstefaníaIcon ; Guzman, Maria LauraIcon ; Olivera, Maria EugeniaIcon ; Marco, Jorge DiegoIcon ; Barroso, Paola AndreaIcon ; Carrer, Dolores CatalinaIcon
Fecha de publicación: 27/01/2021
Editorial: Springer
Revista: Drug Delivery and Translational Research
ISSN: 2190-393X
e-ISSN: 2190-3948
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Farmacología y Farmacia

Resumen

Cutaneous leishmaniasis (CL) is a neglected tropical disease endemic in ~ 90 countries, with an increasing incidence. Presently available pharmacotherapy implies the systemic administration of moderately/very toxic drugs. Miltefosine (Milt) is the only FDA-approved drug to treat CL via the oral route (Impavido®). It produces side effects; in particular, teratogenic effects are of concern. A topical treatment would have the great advantage of minimising the systemic circulation of the drug, preventing side effects. We prepared dispersions containing Milt and liposomes of different compositions to enhance/modulate trans-epidermal penetration and evaluated in vitro and in vivo efficacy and toxicity, in vitro release rate of the drug and particles size stability with time. Treatments were topically administered to BALB/c mice infected with Leishmania (Leishmania) amazonensis. The dispersions containing 0.5% Milt eliminated 99% of the parasites and cured the lesions with a complete re-epithelisation, no visible scar and re-growth of hair. Fluid liposomes decreased the time to heal the lesion and the time needed to eliminate viable amastigotes from the lesion site. Relapse of the infection was not found 1 month after treatment in any case. Ultraflexible liposomes on the other hand had no significant in vitro effect but decreased in vivo efficacy. A topical Milt formulation including fluid liposomes seems a promising treatment against CL. Graphical abstract: [Figure not available: see fulltext.].
Palabras clave: CUTANEOUS LEISHMANIASIS , LIPOSOMES , MILTEFOSINE , PENETRATION ENHANCERS , TOPICAL TREATMENT
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/135460
DOI: https://doi.org/10.1007/s13346-021-00896-8
URL: https://link.springer.com/article/10.1007/s13346-021-00896-8
Colecciones
Articulos(CITEQ)
Articulos de CENTRO DE INVESTIGACION Y TECNOLOGIA QUIMICA
Articulos(IPE)
Articulos de INST.DE PATOLOGIA EXPERIMENTAL
Articulos(UNITEFA)
Articulos de UNIDAD DE INVESTIGACION Y DESARROLLO EN TECNOLOGIA FARMACEUTICA
Citación
Peralta, Maria Florencia; Usseglio, Nadina Aimé; Bracamonte, María Estefanía; Guzman, Maria Laura; Olivera, Maria Eugenia; et al.; Efficacy of topical Miltefosine formulations in an experimental model of cutaneous leishmaniasis; Springer; Drug Delivery and Translational Research; 27-1-2021; 1-17
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