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dc.contributor.author
Nicolás, Paula
dc.contributor.author
Saleta, Martin Eduardo
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Troiani, Horacio Esteban
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Zysler, Roberto Daniel
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Lassalle, Verónica Leticia
dc.contributor.author
Ferreira, Maria Lujan
dc.date.available
2017-03-03T19:49:23Z
dc.date.issued
2013-01
dc.identifier.citation
Nicolás, Paula; Saleta, Martin Eduardo; Troiani, Horacio Esteban; Zysler, Roberto Daniel; Lassalle, Verónica Leticia; et al.; Preparation of iron oxide nanoparticles stabilized with biomolecules: Experimental and mechanistic issues; Elsevier; Acta Biomaterialia; 9; 1; 1-2013; 4754-4762
dc.identifier.issn
1742-7061
dc.identifier.uri
http://hdl.handle.net/11336/13512
dc.description.abstract
Nanoparticles (NPs) with magnetic properties based on magnetite (Fe3O4, MAG) modified with oleic acid (OA), chitosan (CS) and bovine serum albumin (BSA) have been prepared. A versatile method of synthesis was employed, involving two steps: (i) co-precipitation of MAG; and (ii) nanoprecipitation of macromolecules on as-formed MAG NPs. Experimental variables have been explored to determine the set of conditions that ensure suitable properties of NPs in terms of their size, functionality and magnetic properties. It was found that the presence of OA in Fe+2/Fe+3 solutions yields MAG NPs with lower aggregation levels, while increasing initial amounts of OA may change the capability of NPs to disperse in aqueous or organic media by modifying the stabilization mechanism. Incorporation of CS was verified through Fourier transform IR spectroscopy. This biopolymer stabilizes NPs by electrostatic repulsions leading to stable ferrofluids and minimal fraction of recoverable solid NPs. BSA was successfully added to NP formulations, increasing their functionality and probably their biocompatibility. In this case too stable ferrofluids were obtained, where BSA acts as a polyelectrolyte. From the proposed methodology it is possible to achieve a wide range of NPs magnetically active intended for several applications. The required properties may be obtained by varying experimental conditions.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Magnetic Nanoparticles
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Co-Precipitation
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Chitosan
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Oleic Acid
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Bovine Serum Albumin
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Química Inorgánica y Nuclear
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Ciencias Químicas
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CIENCIAS NATURALES Y EXACTAS
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Nano-materiales
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Nanotecnología
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INGENIERÍAS Y TECNOLOGÍAS
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Bioproductos, Biomateriales, Bioplásticos, Biocombustibles, Bioderivados, etc.
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Biotecnología Industrial
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INGENIERÍAS Y TECNOLOGÍAS
dc.title
Preparation of iron oxide nanoparticles stabilized with biomolecules: Experimental and mechanistic issues
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-03-03T18:21:46Z
dc.journal.volume
9
dc.journal.number
1
dc.journal.pagination
4754-4762
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Nicolás, Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); Argentina. Universidad Nacional del Sur; Argentina
dc.description.fil
Fil: Saleta, Martin Eduardo. Comisión Nacional de Energía Atómica. Gerencia del Area de Investigación y Aplicaciones No Nucleares. Gerencia de Física (Centro Atómico Bariloche); Argentina
dc.description.fil
Fil: Troiani, Horacio Esteban. Comisión Nacional de Energía Atómica. Gerencia del Area de Investigación y Aplicaciones No Nucleares. Gerencia de Física (Centro Atómico Bariloche); Argentina
dc.description.fil
Fil: Zysler, Roberto Daniel. Comisión Nacional de Energía Atómica. Gerencia del Area de Investigación y Aplicaciones No Nucleares. Gerencia de Física (Centro Atómico Bariloche); Argentina
dc.description.fil
Fil: Lassalle, Verónica Leticia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Instituto de Química del Sur; Argentina. Universidad Nacional del Sur; Argentina
dc.description.fil
Fil: Ferreira, Maria Lujan. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); Argentina. Universidad Nacional del Sur; Argentina
dc.journal.title
Acta Biomaterialia
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1742706112004771
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.actbio.2012.09.040
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