Artículo
Lp-PLA2 Activity During Iron Depletion Treatment in Primary IO Patients
Tetzlaff, Walter Francisco
; Martín, Maximiliano Emmanuel; Botta, Eliana Elizabeth
; Saez, María Soledad; Ferraro, Maria Florencia
; Boero, Laura Estela; Sorroche, Patricia B; Arbelbide, Jorge; Brites, Fernando Daniel
; Meroño, Tomás
Fecha de publicación:
02/2019
Editorial:
Sryahwa Publications
Revista:
Archives of Hematology and Blood Diseases
ISSN:
2639-3581
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Background: Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an inflammatory biomarker involved in atherosclerosis and cardiovascular disease (CVD). Iron stores may modify Lp-PLA2 as higher activity levels wereobserved in patients with primary iron overload (IO).Aim: to evaluate the changes of Lp-PLA2 activity and other atherosclerosis markers in patients with primary IO after iron depletion.Materials and Methods:The study initially included 20 male patients with primary IO, defined by liver histology,from which 7 were lost during follow-up and 13 completed the study (mean follow-up duration: 24±6 months).Phlebotomy treatment consisted in the removal of 1 unit of blood weekly or biweekly. We recorded traditional cardiovascular risk factors, high sensitivity C-reactive protein (hsCRP), and Lp-PLA2 activity. Longitudinal differences were tested by paired T or Wilcoxon tests. Linear regression was used to evaluate the relationship between changes in ferritin and in Lp-PLA2.Results: HFE mutations were present in 77% of the patients. Besides ferritin concentration (-74%), ALT (-11%) and Lp-PLA2 activities (-14%) were reduced after iron depletion (all p<0.05). Linear regression showed that changes in ferritin levels explained a 60% of the variability in the changes of Lp-PLA2 activity (B=0.80, p=0.008, R2 = 0.60).Conclusions: Treatment by phlebotomy significantly reduced the levels of Lp-PLA2 activity besides its expected effects in liver markers. The implications of iron depletion for the reduction of CVD risk remain to be studied.
Palabras clave:
IRON OVERLOAD
,
PHLEBOTOMY
,
LP-PLA2
,
HSCRP
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Tetzlaff, Walter Francisco; Martín, Maximiliano Emmanuel; Botta, Eliana Elizabeth; Saez, María Soledad; Ferraro, Maria Florencia; et al.; Lp-PLA2 Activity During Iron Depletion Treatment in Primary IO Patients; Sryahwa Publications; Archives of Hematology and Blood Diseases; 2; 2-2019; 8-11
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