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dc.contributor.author
Bernabeu, Ezequiel Adrian
dc.contributor.author
Gonzalez, Lorena
dc.contributor.author
Cagel, Carlos Maximiliano
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Moretton, Marcela Analía
dc.contributor.author
Chiappetta, Diego Andrés
dc.date.available
2021-06-25T14:25:45Z
dc.date.issued
2019-04
dc.identifier.citation
Bernabeu, Ezequiel Adrian; Gonzalez, Lorena; Cagel, Carlos Maximiliano; Moretton, Marcela Analía; Chiappetta, Diego Andrés; Deoxycholate-TPGS mixed nanomicelles for encapsulation of methotrexate with enhanced in vitro cytotoxicity on breast cancer cell lines; Editions Sante; Journal of Drug Delivery Science and Technology; 50; 4-2019; 293-304
dc.identifier.issn
1773-2247
dc.identifier.uri
http://hdl.handle.net/11336/134951
dc.description.abstract
Biocompatible mixed nanomicelles consisting of sodium deoxycholate and D-α-tocopheryl polyethylene glycol 1000 succinate have been prepared in different molar ratios (100:0, 75:25, 50:50, 25:75 and 0:100) in order to improve the aqueous solubility and in vitro anti-tumor activity of methotrexate. The nanomicelles loaded with methotrexate were prepared without using any organic solvents and characterized in terms of critical micellar concentration, particle size and drug solubilization capacity of the micellar dispersion. The optimized formulation (ratio 25:75) exhibited a spherical shape and a particle size of about 8 nm. The results of the in vitro release assay showed that the micellar system presented a sustained release behaviour compared to the solution of methotrexate. Cell viability studies in MCF-7 and MDA-MB-231 cells revealed that mixed micelles achieved lower IC 50 values, in comparison to methotrexate and pralatrexate solutions. The formulated system showed a significant increase in the methotrexate cellular uptake, when compared to the free drug in both cell lines. Furthermore, hemolytic assay confirmed that methotrexate-loaded mixed micelles are compatible with red blood cells. Therefore, the mixed micelles developed in this study might be a potential nano-drug delivery system capable of overcoming in vitro resistance to methotrexate in breast cancer cells.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Editions Sante
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
BREAST CANCER CELL LINES
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IN VITRO ANTI-TUMORAL ACTIVITY
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METHOTREXATE
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MIXED MICELLES
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PRALATREXATE
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TPGS
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Otras Nanotecnología
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Nanotecnología
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INGENIERÍAS Y TECNOLOGÍAS
dc.title
Deoxycholate-TPGS mixed nanomicelles for encapsulation of methotrexate with enhanced in vitro cytotoxicity on breast cancer cell lines
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-03-26T20:00:55Z
dc.journal.volume
50
dc.journal.pagination
293-304
dc.journal.pais
Francia
dc.description.fil
Fil: Bernabeu, Ezequiel Adrian. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
dc.description.fil
Fil: Gonzalez, Lorena. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
dc.description.fil
Fil: Cagel, Carlos Maximiliano. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
dc.description.fil
Fil: Moretton, Marcela Analía. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina
dc.description.fil
Fil: Chiappetta, Diego Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina
dc.journal.title
Journal of Drug Delivery Science and Technology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1773224718313315
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.jddst.2019.01.041
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