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dc.contributor.author
Martínez Rodríguez, Juliana
dc.contributor.author
Renou, Sandra Judith
dc.contributor.author
Guglielmotti, Maria Beatriz
dc.contributor.author
Olmedo, Daniel Gustavo
dc.date.available
2021-06-24T17:15:54Z
dc.date.issued
2019-04
dc.identifier.citation
Martínez Rodríguez, Juliana; Renou, Sandra Judith; Guglielmotti, Maria Beatriz; Olmedo, Daniel Gustavo; Tissue response to porous high density polyethylene as a three-dimensional scaffold for bone tissue engineering: An experimental study; Vsp Bv; Journal of Biomaterials Science - Polymer Edition; 30; 6; 4-2019; 486-499
dc.identifier.issn
0920-5063
dc.identifier.uri
http://hdl.handle.net/11336/134872
dc.description.abstract
High density polyethylene (HDPE) is a synthetic biomaterial used as a three-dimensional scaffold for bone defect reconstruction. Reports differ with regard to its biological response, particularly its osteoconductive capacity. The aim of the present work was to histologically and histomorphometrically evaluate tissue response to porous HDPE. An in vivo study was conducted in rat tibia to evaluate osteogenic capacity, angiogenesis, inflammatory response, and the presence of multinucleated giant cells 14 and 60 days post-biomaterial implantation. Histological examination 14 days post-implantation showed fibrovascular tissue inside pores and on the surface of porous HDPE, acute inflammatory response, scant multinucleated giant cells (MNGCs), and lamellar bone in contact with the biomaterial. An increase in the proportion of lamellar bone tissue, no inflammatory response, and a decrease in the number of MNGCs were observed at 60 days. The histomorphometric study showed a significant time-dependent increase both in the area of bone tissue formed in contact with the porous HDPE (14d: 24.450 ± 11.623 µm 2 vs. 60d: 77.104 ± 26.217 µm 2 , p < 0.05) and in the percentage of bone tissue in contact with the porous HDPE (osseointegration). A significant decrease in the number of MNGCs was also observed at 60 days post-implantation. Porous HDPE showed adequate osteoconductive properties, and only caused an initial inflammatory response. Although this biomaterial has traditionally been used juxtaosseoulsy, its adequate osteoconductive properties broaden the scope of its application to include intraosseous placement.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Vsp Bv
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
BIOMATERIALS
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BONE REGENERATION
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OSTEOGENESIS
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POROUS HIGH DENSITY POLYETHYLENE
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THREE-DIMENSIONAL SCAFFOLDS
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Otras Ciencias de la Salud
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Tissue response to porous high density polyethylene as a three-dimensional scaffold for bone tissue engineering: An experimental study
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-03-26T20:00:21Z
dc.journal.volume
30
dc.journal.number
6
dc.journal.pagination
486-499
dc.journal.pais
Países Bajos
dc.description.fil
Fil: Martínez Rodríguez, Juliana. Universidad de Buenos Aires. Facultad de Odontología; Argentina
dc.description.fil
Fil: Renou, Sandra Judith. Universidad de Buenos Aires. Facultad de Odontología; Argentina
dc.description.fil
Fil: Guglielmotti, Maria Beatriz. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
dc.description.fil
Fil: Olmedo, Daniel Gustavo. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
dc.journal.title
Journal of Biomaterials Science - Polymer Edition
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/09205063.2019.1582278
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1080/09205063.2019.1582278
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