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dc.contributor.author
Ferreira, V.
dc.contributor.author
Velloso, María Inés
dc.contributor.author
Landoni, Maria Fabiana
dc.date.available
2021-06-23T16:04:17Z
dc.date.issued
2020-12
dc.identifier.citation
Ferreira, V.; Velloso, María Inés; Landoni, Maria Fabiana; Bioavailability of butorphanol after intranasal administration to horses; Trakia University; Bulgarian Journal of Veterinary Medicine; 23; 4; 12-2020; 443-447
dc.identifier.issn
1311-1477
dc.identifier.uri
http://hdl.handle.net/11336/134751
dc.description.abstract
The aim of the present study was to describe butorphanol pharmacokinetics and bioavailability following intranasal administration to horses. Six adult horses received 0.05 mg/kg butorphanol, in a randomised crossover design, by either intravenous or intranasal route. Plasma concentrations of bu-torphanol were measured at predetermined time points using liquid chromatography/mass spectrome-try assay. After intravenous injection, mean ±SD butorphanol steady-state volume of distribution and clearance was 3.20 ± 1.77 L/kg and 3.18 ± 1.47 L/kg/h, respectively. Terminal half-lives for butor-phanol after intravenous and intranasal administrations were 0.68 ± 0.17 h and 1.79 ± 1.43 h. For intranasal administration, absorption half-life and peak plasma concentration were 0.43 ± 0.33 h and 1.95 ± 1.7 ng/mL, respectively. Bioavailability was 54.45 ± 20.09%. Intranasal butorphanol administration in horses is practical, not stressful and well tolerated. Therefore, it might be a substitute to the intravenous route in adult horses.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Trakia University
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
BIOAVAILABILITY
dc.subject
BUTORPHANOL
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HORSES
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INTRANASAL
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PHARMACOKINETICS
dc.subject.classification
Ciencias Veterinarias
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Ciencias Veterinarias
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CIENCIAS AGRÍCOLAS
dc.title
Bioavailability of butorphanol after intranasal administration to horses
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-06-22T19:05:57Z
dc.identifier.eissn
1313-3543
dc.journal.volume
23
dc.journal.number
4
dc.journal.pagination
443-447
dc.journal.pais
Bulgaria
dc.journal.ciudad
Stara Zagora
dc.description.fil
Fil: Ferreira, V.. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
dc.description.fil
Fil: Velloso, María Inés. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
dc.description.fil
Fil: Landoni, Maria Fabiana. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
dc.journal.title
Bulgarian Journal of Veterinary Medicine
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://tru.uni-sz.bg/bjvm/index.html
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.15547/bjvm.2019-0051
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