Repositorio Institucional
Repositorio Institucional
CONICET Digital
  • Inicio
  • EXPLORAR
    • AUTORES
    • DISCIPLINAS
    • COMUNIDADES
  • Estadísticas
  • Novedades
    • Noticias
    • Boletines
  • Ayuda
    • General
    • Datos de investigación
  • Acerca de
    • CONICET Digital
    • Equipo
    • Red Federal
  • Contacto
JavaScript is disabled for your browser. Some features of this site may not work without it.
  • INFORMACIÓN GENERAL
  • RESUMEN
  • ESTADISTICAS
 
Artículo

Polymeric microparticles containing indomethacin for inhalatory administration

Ceschan, Nazareth ElianaIcon ; Bucala, VeronicaIcon ; Ramírez Rigo, María VeronicaIcon
Fecha de publicación: 02/2015
Editorial: Elsevier Science
Revista: Powder Technology
ISSN: 0032-5910
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Ingenierías y Tecnologías

Resumen

Indomethacin (IN) is a non-steroidal antiinflammatory drug. It reduces pain and inflammation in rheumatoid arthritis but its use is associated with high incidence of undesirable gastrointestinal side effects. In addition, its low solubility in water limits its oral bioavailability. In this work, microparticles based on an IN-polylysine (PL) complex were obtained by spray drying. The system is intended to deliver the drug through the inhalatory route for both local and systemic treatments. Several formulations, varying the relative composition IN/PL-dextrine (DX) and the total solid content of the feed solutions, were tested. The process performance (yield, air outlet temperature), product properties (IN load efficiency, moisture content, crystallinity, glass transition temperature, density, morphology and particle size distribution), the IN- polylysine ionic interaction (assessed by FT-infrared spectroscopy, powder X-ray diffraction and thermal analysis), and in vitro IN release were studied. Powders exhibited high load efficiencies and low moisture contents, and remained in the amorphous state after nine months of storage. The particle systems with 50 % of the polylysine amino groups neutralized by IN were the more attractive ones for pulmonary treatment,since they were easily processed using a Homogeneous aqueous feed, had relatively high IN contents and high cumulative fraction of respirable particles.
Palabras clave: Polyelectrolyte-Drug Complexes , Pulmonary Route , Non-Steroidal Antiinflammatory Drug , Spray Drying , Polylysine , Particle Engineering
Ver el registro completo
 
Archivos asociados
Thumbnail
 
Tamaño: 1.860Mb
Formato: PDF
.
Descargar
Licencia
info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)
Identificadores
URI: http://hdl.handle.net/11336/13467
URL: http://www.sciencedirect.com/science/article/pii/S0032591015001114
DOI: http://dx.doi.org/10.1016/j.powtec.2015.02.001
Colecciones
Articulos(PLAPIQUI)
Articulos de PLANTA PILOTO DE INGENIERIA QUIMICA (I)
Citación
Ceschan, Nazareth Eliana; Bucala, Veronica; Ramírez Rigo, María Veronica; Polymeric microparticles containing indomethacin for inhalatory administration; Elsevier Science; Powder Technology; 285; 2-2015; 51-61
Compartir
Altmétricas
 

Enviar por e-mail
Separar cada destinatario (hasta 5) con punto y coma.
  • Facebook
  • X Conicet Digital
  • Instagram
  • YouTube
  • Sound Cloud
  • LinkedIn

Los contenidos del CONICET están licenciados bajo Creative Commons Reconocimiento 2.5 Argentina License

https://www.conicet.gov.ar/ - CONICET

Inicio

Explorar

  • Autores
  • Disciplinas
  • Comunidades

Estadísticas

Novedades

  • Noticias
  • Boletines

Ayuda

Acerca de

  • CONICET Digital
  • Equipo
  • Red Federal

Contacto

Godoy Cruz 2290 (C1425FQB) CABA – República Argentina – Tel: +5411 4899-5400 repositorio@conicet.gov.ar
TÉRMINOS Y CONDICIONES