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dc.contributor.author
Valdés Hernández, Maria del C.
dc.contributor.author
Abu Hussain, Janna
dc.contributor.author
Qiu, Xinyi
dc.contributor.author
Priller, Josef
dc.contributor.author
Parra Rodríguez, Mario
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Pino, Mariana
dc.contributor.author
Báez, Sandra
dc.contributor.author
Ibañez, Agustin Mariano
dc.date.available
2021-06-22T15:59:33Z
dc.date.issued
2019-07
dc.identifier.citation
Valdés Hernández, Maria del C.; Abu Hussain, Janna; Qiu, Xinyi; Priller, Josef; Parra Rodríguez, Mario; et al.; Structural neuroimaging differentiates vulnerability from disease manifestation in colombian families with Huntington's disease; John Wiley & Sons Inc; Brain and Behavior; 9; 8; 7-2019; 1-13
dc.identifier.issn
2162-3279
dc.identifier.uri
http://hdl.handle.net/11336/134656
dc.description.abstract
Introduction: The volume of the striatal structures has been associated with disease progression in individuals with Huntington's disease (HD) from North America, Europe, and Australia. However, it is not known whether the gray matter (GM) volume in the striatum is also sensitive in differentiating vulnerability from disease manifestation in HD families from a South-American region known to have high incidence of the disease. In addition, the association of enlarged brain perivascular spaces (PVS) with cognitive, behavioral, and motor symptoms of HD is unknown. Materials and Methods: We have analyzed neuroimaging indicators of global atrophy, PVS burden, and GM tissue volume in the basal ganglia and thalami, in relation to behavioral, motor, and cognitive scores, in 15 HD patients with overt disease manifestation and 14 first-degree relatives not genetically tested, which represent a vulnerable group, from the region of Magdalena, Colombia. Results: Poor fluid intelligence as per the Raven's Standard Progressive Matrices was associated with global brain atrophy (p = 0.002) and PVS burden (p ≤ 0.02) in HD patients, where the GM volume in all subcortical structures, with the exception of the right globus pallidus, was associated with motor or cognitive scores. Only the GM volume in the right putamen was associated with envy and MOCA scores (p = 0.008 and 0.015 respectively) in first-degree relatives. Conclusion: Striatal GM volume, global brain atrophy and PVS burden may serve as differential indicators of disease manifestation in HD. The Raven's Standard Progressive Matrices could be a cognitive test worth to consider in the differentiation of vulnerability versus overt disease in HD.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
John Wiley & Sons Inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
BASAL GANGLIA
dc.subject
COGNITION
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FLUID INTELLIGENCE
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HUNTINGTON'S DISEASE
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MRI
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PERIVASCULAR SPACES
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RAVEN MATRICES
dc.subject.classification
Neurociencias
dc.subject.classification
Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Structural neuroimaging differentiates vulnerability from disease manifestation in colombian families with Huntington's disease
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-11-20T17:41:17Z
dc.journal.volume
9
dc.journal.number
8
dc.journal.pagination
1-13
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Valdés Hernández, Maria del C.. University of Edinburgh; Reino Unido
dc.description.fil
Fil: Abu Hussain, Janna. University of Edinburgh; Reino Unido
dc.description.fil
Fil: Qiu, Xinyi. Glan Clwyd Hospital; Reino Unido
dc.description.fil
Fil: Priller, Josef. University of Edinburgh; Reino Unido
dc.description.fil
Fil: Parra Rodríguez, Mario. University of Strathclyde; Reino Unido. Universidad Autónoma del Caribe; Colombia
dc.description.fil
Fil: Pino, Mariana. Universidad Autónoma del Caribe; Colombia
dc.description.fil
Fil: Báez, Sandra. Universidad de los Andes; Colombia
dc.description.fil
Fil: Ibañez, Agustin Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt | Instituto de Neurología Cognitiva. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt | Fundación Favaloro. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt; Argentina
dc.journal.title
Brain and Behavior
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/brb3.1343
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1002/brb3.1343
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