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dc.contributor.author
Vendrell Navarro, Gloria
dc.contributor.author
Rúa, Federico
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Bujons, Jordi
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Brockmeyer, Andreas
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Janning, Petra
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Ziegler, Slava
dc.contributor.author
Messeguer, Angel
dc.contributor.author
Waldmann, Herbert
dc.date.available
2017-02-24T20:27:06Z
dc.date.issued
2015-07
dc.identifier.citation
Vendrell Navarro, Gloria; Rúa, Federico; Bujons, Jordi; Brockmeyer, Andreas; Janning, Petra ; et al.; Positional scanning synthesis of a Peptoid library yields new inducers of apoptosis that target Karyopherins and Tubulin; Wiley VCH Verlag; Chembiochem; 16; 11; 7-2015; 1580-1587
dc.identifier.uri
http://hdl.handle.net/11336/13406
dc.description.abstract
We describe the synthesis of a library of 11 638 N-alkylglycine peptoid trimers in a positional scanning format with adjustment of reaction conditions to account for different reactivities of the monomer building blocks. Evaluation of the library by high-content phenotypic screening for modulators of the cytoskeleton and mitosis resulted in the identification of two apoptosis-inducing peptoids, which, despite their structural similarity, target different proteins and cellular mechanisms. Whereas one peptoid binds to karyopherins, which mediate nuclear transport, the other N-alkylglycine trimer binds tubulin at the vinca alkaloid binding site.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley VCH Verlag
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Apoptosis
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Química Combinatoria
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Peptidomimeticos
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Relación Estructura-Actividad
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Ciencias de la Computación
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Ciencias de la Computación e Información
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CIENCIAS NATURALES Y EXACTAS
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Química Orgánica
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Ciencias Químicas
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CIENCIAS NATURALES Y EXACTAS
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Biotecnología relacionada con la Salud
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Biotecnología de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Positional scanning synthesis of a Peptoid library yields new inducers of apoptosis that target Karyopherins and Tubulin
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-02-23T13:55:56Z
dc.identifier.eissn
1439-7633
dc.journal.volume
16
dc.journal.number
11
dc.journal.pagination
1580-1587
dc.journal.pais
Alemania
dc.journal.ciudad
Weinheim
dc.description.fil
Fil: Vendrell Navarro, Gloria. Institut Max Planck Fur Molekulare Physiologie; Alemania. Consejo Superior de Investigaciones Cientificas; España
dc.description.fil
Fil: Rúa, Federico. Consejo Superior de Investigaciones Cientificas; España. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Bujons, Jordi. Consejo Superior de Investigaciones Cientificas; España
dc.description.fil
Fil: Brockmeyer, Andreas. Institut Max Planck Fur Molekulare Physiologie; Alemania
dc.description.fil
Fil: Janning, Petra . Institut Max Planck Fur Molekulare Physiologie; Alemania
dc.description.fil
Fil: Ziegler, Slava. Institut Max Planck Fur Molekulare Physiologie; Alemania
dc.description.fil
Fil: Messeguer, Angel. Consejo Superior de Investigaciones Cientificas; España
dc.description.fil
Fil: Waldmann, Herbert. Institut Max Planck Fur Molekulare Physiologie; Alemania. Technische Universitä t Dortmund; Alemania
dc.journal.title
Chembiochem
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/cbic.201500169
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/cbic.201500169/abstract
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