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dc.contributor.author
Goya, María Eugenia  
dc.contributor.author
Xue, Feng  
dc.contributor.author
Sampedro Torres Quevedo, Cristina  
dc.contributor.author
Arnaouteli, Sofia  
dc.contributor.author
Riquelme Dominguez, Lourdes  
dc.contributor.author
Romanowski, Andrés  
dc.contributor.author
Brydon, Jack  
dc.contributor.author
Ball, Kathryn L.  
dc.contributor.author
Stanley-Wall, Nicola R.  
dc.contributor.author
Doitsidou, Maria  
dc.date.available
2021-06-17T13:05:48Z  
dc.date.issued
2020-01  
dc.identifier.citation
Goya, María Eugenia; Xue, Feng; Sampedro Torres Quevedo, Cristina; Arnaouteli, Sofia; Riquelme Dominguez, Lourdes; et al.; Probiotic Bacillus subtilis Protects against α-Synuclein Aggregation in C. elegans; Elsevier; Cell Reports; 30; 2; 1-2020; 367-380.e7  
dc.identifier.issn
2211-1247  
dc.identifier.uri
http://hdl.handle.net/11336/134063  
dc.description.abstract
How the gut microbiome affects Parkinson's disease remains unclear. Goya et al. show that the probiotic B. subtilis strain PXN21 inhibits and clears α-synuclein aggregation in a C. elegans model. The bacterium acts via metabolites and biofilm formation to activate protective pathways in the host, including DAF-16/FOXO and sphingolipid metabolism.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/  
dc.subject
B. SUBTILIS  
dc.subject
BIOFILM  
dc.subject
C. ELEGANS  
dc.subject
DAF-16/FOXO  
dc.subject
DIETARY RESTRICTION  
dc.subject
MICROBIOTA  
dc.subject
PARKINSON'S DISEASE  
dc.subject
PROBIOTICS  
dc.subject
SPHINGOLIPID METABOLISM  
dc.subject
Α-SYNUCLEIN  
dc.subject.classification
Otras Ciencias Biológicas  
dc.subject.classification
Ciencias Biológicas  
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS  
dc.title
Probiotic Bacillus subtilis Protects against α-Synuclein Aggregation in C. elegans  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2020-06-23T15:09:31Z  
dc.identifier.eissn
2211-1247  
dc.journal.volume
30  
dc.journal.number
2  
dc.journal.pagination
367-380.e7  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
Cambridge  
dc.description.fil
Fil: Goya, María Eugenia. University of Edinburgh; Reino Unido  
dc.description.fil
Fil: Xue, Feng. University of Edinburgh; Reino Unido  
dc.description.fil
Fil: Sampedro Torres Quevedo, Cristina. University of Edinburgh; Reino Unido  
dc.description.fil
Fil: Arnaouteli, Sofia. University Of Dundee; Reino Unido  
dc.description.fil
Fil: Riquelme Dominguez, Lourdes. University of Edinburgh; Reino Unido  
dc.description.fil
Fil: Romanowski, Andrés. University of Edinburgh; Reino Unido. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina  
dc.description.fil
Fil: Brydon, Jack. University of Edinburgh; Reino Unido  
dc.description.fil
Fil: Ball, Kathryn L.. University of Edinburgh; Reino Unido  
dc.description.fil
Fil: Stanley-Wall, Nicola R.. University Of Dundee; Reino Unido  
dc.description.fil
Fil: Doitsidou, Maria. University of Edinburgh; Reino Unido  
dc.journal.title
Cell Reports  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31743-7  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.celrep.2019.12.078  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2211124719317437  

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