New perspectives in melatonin uses

This review summarizes the metabolism, secretion, regulation and sites of action of melatonin. An updated description of the melatonin receptors, including their signal transduction mechanisms, distribution and characterization of receptor genes, is given. Special emphasis is focused on the clinical aspects and potential uses of melatonin in the sleep-wake rhythms, in the immune function, in cancer therapy, in neuroprotection against oxidative damage and antioxidant activities in different tissues. Finally, combined effects of melatonin with other drugs are discussed. © 2012 Elsevier Ltd. All rights reserved.

Palabras clave: ANTIOXIDANT PROPERTIES , CANCER , CENTRAL NERVOUS SYSTEM , GASTROINTESTINAL TRACT , MELATONIN METABOLISM , MELATONIN RECEPTORS

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Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)

Identificadores

URI: http://hdl.handle.net/11336/133937

DOI: http://dx.doi.org/10.1016/j.phrs.2012.01.003

Colecciones

Articulos(CCT - CORDOBA)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - CORDOBA

Articulos(INICSA)
Articulos de INSTITUTO DE INVESTIGACIONES EN CIENCIAS DE LA SALUD

Citación

Carpentieri, Agata Rita; Díaz de Barboza, Gabriela Edith; Areco, Vanessa Andrea; Peralta López, María Elena; Tolosa, Nori Graciela; New perspectives in melatonin uses; Academic Press Ltd - Elsevier Science Ltd; Pharmacological Research; 65; 4; 4-2012; 437-444

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