Artículo
The structure of the extended E2 DNA-binding domain of the bovine papillomavirus-1
Leroy, Ludmila; Ribeiro Gonçalves Barbosa, João Alexandre; de Prat Gay, Gonzalo
; Polikarpov, Igor; Basílio Pinheiro, Carlos
Fecha de publicación:
08/2019
Editorial:
Wiley-liss, div John Wiley & Sons Inc.
Revista:
Proteins: Structure, Function And Genetics
ISSN:
0887-3585
e-ISSN:
1097-0134
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Bovine papillomavirus proteins were extensively studied as a prototype for the human papillomavirus. Here, the crystal structure of the extended E2 DNA-binding domain of the dominant transcription regulator from the bovine papillomavirus strain 1 is described in the space group P3121. We found two protein functional dimers packed in the asymmetric unit. This new protein arrangement inside the crystal led to the reduction of the mobility of a previously unobserved loop directly involved in the protein-DNA interaction, which was then modeled for the first time.
Palabras clave:
BOVINE PAPILLOMAVIRUS
,
E2 DNA-BINDING DOMAIN
,
LI LOOP
,
PROTEIN STRUCTURE
Archivos asociados
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Identificadores
Colecciones
Articulos(IIBBA)
Articulos de INST.DE INVEST.BIOQUIMICAS DE BS.AS(I)
Articulos de INST.DE INVEST.BIOQUIMICAS DE BS.AS(I)
Citación
Leroy, Ludmila; Ribeiro Gonçalves Barbosa, João Alexandre; de Prat Gay, Gonzalo; Polikarpov, Igor; Basílio Pinheiro, Carlos; The structure of the extended E2 DNA-binding domain of the bovine papillomavirus-1; Wiley-liss, div John Wiley & Sons Inc.; Proteins: Structure, Function And Genetics; 88; 1; 8-2019; 106-112
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