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dc.contributor.author
Parisi, Gustavo Daniel
dc.contributor.author
Zea, Diego Javier
dc.contributor.author
Monzón, Alexander
dc.contributor.author
Marino Buslje, Cristina
dc.date.available
2021-06-11T12:47:26Z
dc.date.issued
2015-03
dc.identifier.citation
Parisi, Gustavo Daniel; Zea, Diego Javier; Monzón, Alexander; Marino Buslje, Cristina; Conformational diversity and the emergence of sequence signatures during evolution; Current Biology; Current Opinion In Structural Biology; 32; 3-2015; 58-65
dc.identifier.issn
0959-440X
dc.identifier.uri
http://hdl.handle.net/11336/133664
dc.description.abstract
Proteins' native structure is an ensemble of conformers in equilibrium, including all their respective functional states and intermediates. The induced-fit first and the pre-equilibrium theories later, described how structural changes are required to explain the allosteric and cooperative behaviours in proteins, which are key to protein function. The conformational ensemble concept has become a key tool in explaining an endless list of essential protein properties such as function, enzyme and antibody promiscuity, signal transduction, protein-protein recognition, origin of diseases, origin of new protein functions, evolutionary rate and order-disorder transitions, among others. Conformational diversity is encoded by the amino acid sequence and such a signature can be evidenced through evolutionary studies as evolutionary rate, conservation and coevolution.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Current Biology
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
PROTEINS
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EVOLUTION
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CONFORMATIONAL DIVERSITY
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COEVOLUTION
dc.subject.classification
Bioquímica y Biología Molecular
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Conformational diversity and the emergence of sequence signatures during evolution
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-07-31T14:14:55Z
dc.identifier.eissn
1879-033X
dc.journal.volume
32
dc.journal.pagination
58-65
dc.journal.pais
Países Bajos
dc.description.fil
Fil: Parisi, Gustavo Daniel. Universidad Nacional de Quilmes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Zea, Diego Javier. Universidad Nacional de Quilmes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
dc.description.fil
Fil: Monzón, Alexander. Universidad Nacional de Quilmes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Marino Buslje, Cristina. Fundación Instituto Leloir; Argentina
dc.journal.title
Current Opinion In Structural Biology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0959440X15000147
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.sbi.2015.02.005