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dc.contributor.author
Gonzalez, Marianela
dc.contributor.author
Vaillard, Santiago Eduardo
dc.contributor.author
Grau, Ricardo Jose Antonio
dc.date.available
2017-02-24T13:56:02Z
dc.date.issued
2011-12
dc.identifier.citation
Gonzalez, Marianela; Vaillard, Santiago Eduardo; Grau, Ricardo Jose Antonio; Pegylation: an overview and recent advances reported in the patent literature; Bentham Science Publishers; Recent Patents on Chemical Engineering; 4; 3; 12-2011; 241-264
dc.identifier.issn
2211-3347
dc.identifier.uri
http://hdl.handle.net/11336/13353
dc.description.abstract
Pegylation technologies have improved since chemistry and purification processes have advanced over the years. Furthermore, a gradual better understanding of the clinical responses has spurred the need for more effective therapeutic agents. Nowadays, it is necessary to early identify therapy needs and technical capabilities to develop customized, innovative products that reach the market successfully. Consequently, the main technical efforts are directed to solve some intricate problems associated with the drug delivery where improved solubility, in vivo stability, targeted delivery, and enhanced efficacy and safety are the major challenges. Too many alternative approaches for too many needs open up the possibility for follow-on developers and competitors, and provide opportunities for innovation that provoke an intense worldwide competition in a complex intellectual property environment. This paper presents an overview of general trends and patents supporting PEGylation platforms. Since the golden rule is that PEGylation has to be tailored to each specific drug and application, the review format is structured by specific conjugated species alphabetically sorted within the following groups: PEG-protein conjugates, PEG-antibody and antibody fragment conjugates, PEG-oligonucleotide conjugates, PEG-small molecule drug conjugates, and PEGylated materials and miscellaneous applications.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Bentham Science Publishers
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Pegylation
dc.subject
Drug Delivery
dc.subject
Patented Conjugates
dc.subject
Pegylated Drugs
dc.subject.classification
Otras Nanotecnología
dc.subject.classification
Nanotecnología
dc.subject.classification
INGENIERÍAS Y TECNOLOGÍAS
dc.title
Pegylation: an overview and recent advances reported in the patent literature
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-02-17T13:26:02Z
dc.journal.volume
4
dc.journal.number
3
dc.journal.pagination
241-264
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Gonzalez, Marianela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Vaillard, Santiago Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química (i); Argentina
dc.description.fil
Fil: Grau, Ricardo Jose Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química (i); Argentina. Universidad Nacional del Litoral; Argentina
dc.journal.title
Recent Patents on Chemical Engineering
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.2174/1874478811104030241
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/94769/article
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