Mostrar el registro sencillo del ítem
dc.contributor.author
Zhao, Yu
dc.contributor.author
Cao, Hung
dc.contributor.author
Beebe, Tyler
dc.contributor.author
Zhang, Hemin
dc.contributor.author
Zhang, Xiaoxiao
dc.contributor.author
Chang, Honglong
dc.contributor.author
Scremin, Oscar Umberto
dc.contributor.author
Lien, Ching Ling
dc.contributor.author
Tai, Yu Chong
dc.contributor.author
Hsiai, Tzung K.
dc.date.available
2017-02-23T20:48:38Z
dc.date.issued
2015-04
dc.identifier.citation
Zhao, Yu; Cao, Hung; Beebe, Tyler; Zhang, Hemin; Zhang, Xiaoxiao; et al.; Dry-contact microelectrode membranes for wireless detection of electrical phenotypes in neonatal mouse hearts; Springer; Biomedical Microdevices; 17; 4-2015; 1-6
dc.identifier.issn
1387-2176
dc.identifier.uri
http://hdl.handle.net/11336/13340
dc.description.abstract
Continuous monitoring of aberrant electrical rhythms during heart injury and repair requires prolonged data acquisition. We hereby developed a wearable microelectrode membrane that could be adherent to the chest of neonatal mice for in situ wireless recording of electrocardiogram (ECG) signals. The novel dry-contact membrane with a meshed parylene-C pad adjacent to the microelectrodes and the expandable meandrous strips allowed for varying size of the neonates. The performance was evaluated at the system level; specifically, the ECG signals (μV) acquired from the microelectrodes underwent two-stage amplification, band-pass filtering, and optical data transmission by an infrared Light Emitting Diode (LED) to the data-receiving unit. The circuitry was prototyped on a printed circuit board (PCB), consuming less than 300 μW, and was completely powered by an inductive coupling link. Distinct P waves, QRS complexes, and T waves of ECG signals were demonstrated from the non-pharmacologically sedated neonates at ~600 beats per minutes. Thus, we demonstrate the feasibility of both real-time and wireless monitoring cardiac rhythms in a neonatal mouse (17–20 mm and <1 g) via dry-contact microelectrode membrane; thus, providing a basis for diagnosing aberrant electrical conduction in animal models of cardiac injury and repair.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Neonatal Mice
dc.subject
Wireless Monitoring
dc.subject
Dry-Contact Electrodes
dc.subject
Ecg
dc.subject
Heart Regeneration
dc.subject.classification
Biofísica
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Dry-contact microelectrode membranes for wireless detection of electrical phenotypes in neonatal mouse hearts
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-02-23T13:55:48Z
dc.identifier.eissn
1572-8781
dc.journal.volume
17
dc.journal.pagination
1-6
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Nueva York
dc.description.fil
Fil: Zhao, Yu. California Institute Of Technology; Estados Unidos
dc.description.fil
Fil: Cao, Hung. University of California at Los Angeles; Estados Unidos
dc.description.fil
Fil: Beebe, Tyler. University of California at Los Angeles; Estados Unidos
dc.description.fil
Fil: Zhang, Hemin. Northwestern Polytechnical University; China
dc.description.fil
Fil: Zhang, Xiaoxiao. California Institute Of Technology; Estados Unidos
dc.description.fil
Fil: Chang, Honglong. Northwestern Polytechnical University; China
dc.description.fil
Fil: Scremin, Oscar Umberto. Veteran Affairs Greater Los Angeles Healthcare System; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Lien, Ching Ling. Children Hospital Los Angeles; Estados Unidos
dc.description.fil
Fil: Tai, Yu Chong. California Institute Of Technology; Estados Unidos
dc.description.fil
Fil: Hsiai, Tzung K.. University of California at Los Angeles; Estados Unidos. Veteran Affairs Greater Los Angeles Healthcare System; Estados Unidos
dc.journal.title
Biomedical Microdevices
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/ 10.1007/s10544-014-9912-y
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://link.springer.com/article/10.1007%2Fs10544-014-9912-y
Archivos asociados