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dc.contributor.author
Zhao, Yu
dc.contributor.author
Cao, Hung
dc.contributor.author
Beebe, Tyler
dc.contributor.author
Zhang, Hemin
dc.contributor.author
Zhang, Xiaoxiao
dc.contributor.author
Chang, Honglong
dc.contributor.author
Scremin, Oscar Umberto
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dc.contributor.author
Lien, Ching Ling
dc.contributor.author
Tai, Yu Chong
dc.contributor.author
Hsiai, Tzung K.
dc.date.available
2017-02-23T20:48:38Z
dc.date.issued
2015-04
dc.identifier.citation
Zhao, Yu; Cao, Hung; Beebe, Tyler; Zhang, Hemin; Zhang, Xiaoxiao; et al.; Dry-contact microelectrode membranes for wireless detection of electrical phenotypes in neonatal mouse hearts; Springer; Biomedical Microdevices; 17; 4-2015; 1-6
dc.identifier.issn
1387-2176
dc.identifier.uri
http://hdl.handle.net/11336/13340
dc.description.abstract
Continuous monitoring of aberrant electrical rhythms during heart injury and repair requires prolonged data acquisition. We hereby developed a wearable microelectrode membrane that could be adherent to the chest of neonatal mice for in situ wireless recording of electrocardiogram (ECG) signals. The novel dry-contact membrane with a meshed parylene-C pad adjacent to the microelectrodes and the expandable meandrous strips allowed for varying size of the neonates. The performance was evaluated at the system level; specifically, the ECG signals (μV) acquired from the microelectrodes underwent two-stage amplification, band-pass filtering, and optical data transmission by an infrared Light Emitting Diode (LED) to the data-receiving unit. The circuitry was prototyped on a printed circuit board (PCB), consuming less than 300 μW, and was completely powered by an inductive coupling link. Distinct P waves, QRS complexes, and T waves of ECG signals were demonstrated from the non-pharmacologically sedated neonates at ~600 beats per minutes. Thus, we demonstrate the feasibility of both real-time and wireless monitoring cardiac rhythms in a neonatal mouse (17–20 mm and <1 g) via dry-contact microelectrode membrane; thus, providing a basis for diagnosing aberrant electrical conduction in animal models of cardiac injury and repair.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Neonatal Mice
dc.subject
Wireless Monitoring
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Dry-Contact Electrodes
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Ecg
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Heart Regeneration
dc.subject.classification
Biofísica
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dc.subject.classification
Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
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dc.title
Dry-contact microelectrode membranes for wireless detection of electrical phenotypes in neonatal mouse hearts
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-02-23T13:55:48Z
dc.identifier.eissn
1572-8781
dc.journal.volume
17
dc.journal.pagination
1-6
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Nueva York
dc.description.fil
Fil: Zhao, Yu. California Institute Of Technology; Estados Unidos
dc.description.fil
Fil: Cao, Hung. University of California at Los Angeles; Estados Unidos
dc.description.fil
Fil: Beebe, Tyler. University of California at Los Angeles; Estados Unidos
dc.description.fil
Fil: Zhang, Hemin. Northwestern Polytechnical University; China
dc.description.fil
Fil: Zhang, Xiaoxiao. California Institute Of Technology; Estados Unidos
dc.description.fil
Fil: Chang, Honglong. Northwestern Polytechnical University; China
dc.description.fil
Fil: Scremin, Oscar Umberto. Veteran Affairs Greater Los Angeles Healthcare System; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Lien, Ching Ling. Children Hospital Los Angeles; Estados Unidos
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Fil: Tai, Yu Chong. California Institute Of Technology; Estados Unidos
dc.description.fil
Fil: Hsiai, Tzung K.. University of California at Los Angeles; Estados Unidos. Veteran Affairs Greater Los Angeles Healthcare System; Estados Unidos
dc.journal.title
Biomedical Microdevices
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/ 10.1007/s10544-014-9912-y
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://link.springer.com/article/10.1007%2Fs10544-014-9912-y
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