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dc.contributor.author
Mallet, Jean-Francois
dc.contributor.author
Duarte, Jairo
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Vinderola, Celso Gabriel
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dc.contributor.author
Anquenot, Raphael
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Beauliau, Martin
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Matar, Chantal
dc.date.available
2017-02-23T18:53:52Z
dc.date.issued
2014-06
dc.identifier.citation
Mallet, Jean-Francois; Duarte, Jairo; Vinderola, Celso Gabriel; Anquenot, Raphael; Beauliau, Martin; et al.; The immunopotentiating effects of shark-derived protein hydrolysate.; Elsevier Science Inc; Nutrition; 30; 6-2014; 706-712
dc.identifier.issn
0899-9007
dc.identifier.uri
http://hdl.handle.net/11336/13332
dc.description.abstract
Peptides derived from natural sources can act as immunomodulating agents and prevent infections. The aim of this study was to investigate the immunopotentiating and protective effects of a shark-derived protein hydrolysate (SPH) against an enterotoxigenic Escherichia coli H10407 infection in a murine model. METHODS: Mice were fed an aqueous solution of SPH for 7 days before being inoculated with an experimental enterotoxigenic Escherichia coli H10407 infection. After euthanasia, small intestines were removed for histological study and the number of IgA and IgG producing cells was determined by direct immunofluorescence. Cytokines were measured in the serum and the intestinal fluid. RESULTS: The oral administration of SPH enhanced the gut barrier function via up-regulation of immunoglobulin A-producing cells and intestinal cytokines production, including interleukin-6 and tumor necrosis factor-α. The increase of transforming growth factor-β and interleukin-10 contribute to the down-regulation of uncontrolled-inflammatory reaction induced by E. coli infection. From these results, the anti-inflammatory properties of SPH may be caused by regulation and priming mechanisms of the immune system. CONCLUSION: Enzymatic protein degradation confers immunomodulating and protective potentials to shark proteins and the resulted peptides could be used as an alternative therapy to reduce the risk of bacterial infections and inflammatory-related diseases.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science Inc
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Shark-Derives Protein Hydrolysate
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Immunomodulation
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Intestinal Mucosa
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Enterotoxigenic E. Coli Infection
dc.subject.classification
Alimentos y Bebidas
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Otras Ingenierías y Tecnologías
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INGENIERÍAS Y TECNOLOGÍAS
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dc.title
The immunopotentiating effects of shark-derived protein hydrolysate.
dc.type
info:eu-repo/semantics/article
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info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-11-23T20:13:19Z
dc.journal.volume
30
dc.journal.pagination
706-712
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Mallet, Jean-Francois. University of Ottawa. Faculty of Healt Sciences. Nutrition Sciences Program; Canadá
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Fil: Duarte, Jairo. University of Ottawa. Faculty of Healt Sciences. Nutrition Sciences Program; Canadá
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Fil: Vinderola, Celso Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Lactologia Industrial; Argentina
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Fil: Anquenot, Raphael. InnoVactiv Inc.; Canadá
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Fil: Beauliau, Martin. InnoVactiv Inc.; Canadá
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Fil: Matar, Chantal. University of Ottawa. Faculty of Healt Sciences. Nutrition Sciences Program; Canadá
dc.journal.title
Nutrition
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.nut.2013.10.025
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