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dc.contributor.author
Simian, Marina
dc.contributor.author
Raffo, Diego Alejandro
dc.contributor.author
Pontiggia, Osvaldo Alejandro
dc.date.available
2017-02-22T19:57:33Z
dc.date.issued
2011-04
dc.identifier.citation
Simian, Marina; Raffo, Diego Alejandro; Pontiggia, Osvaldo Alejandro; Role of MMPs in Metastatic Dissemination: Implications for Therapeutic Advances; Bentham Science Publishers; Current Pharmaceutical Biotechnology; 12; 11; 4-2011; 1937-1947
dc.identifier.issn
1389-2010
dc.identifier.uri
http://hdl.handle.net/11336/13328
dc.description.abstract
Matrix metalloproteinases (MMPs) have been implicated in both normal and pathologic processes. In cancer in particular, in vitro and animal studies showed an involvement of MMPs in many stages of cancer progression. This led to the development of MMP inhibitors that in most cases failed in clinical trials. In this review we go over the role of MMPs in the different stages of cancer progression and try to understand why the early generation of MMP inhibitors failed. The analysis of the lessons from this first experience, plus the review of the current knowledge that shows that MMPs may be pro-or anti-tumorigenic may set the stage for a future success for this therapeutic strategy in cancer.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Bentham Science Publishers
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Cancer
dc.subject
Clinical Trials
dc.subject
Mmp
dc.subject
Mmp Inhibitors
dc.subject
Therapy
dc.subject.classification
Bioquímica y Biología Molecular
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Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Role of MMPs in Metastatic Dissemination: Implications for Therapeutic Advances
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-02-15T14:09:47Z
dc.journal.volume
12
dc.journal.number
11
dc.journal.pagination
1937-1947
dc.journal.pais
Emiratos Árabes Unidos
dc.journal.ciudad
Sharjah
dc.description.fil
Fil: Simian, Marina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncologia "Angel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
dc.description.fil
Fil: Raffo, Diego Alejandro. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncologia "Angel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
dc.description.fil
Fil: Pontiggia, Osvaldo Alejandro. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncologia "Angel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
dc.journal.title
Current Pharmaceutical Biotechnology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.ingentaconnect.com/content/ben/cpb/2011/00000012/00000011/art00021
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.2174/138920111798377085
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