Artículo
Charge Discrimination in P2X4 Receptors Occurs in Two Consecutive Stages
Pierdominici Sottile, Gustavo
; Racigh, Vanesa Elizabeth
; Ormazábal, Agustín
; Palma, Juliana Isabel
![Icon](/themes/CONICETDigital/images/conicet.png)
![Icon](/themes/CONICETDigital/images/conicet.png)
![Icon](/themes/CONICETDigital/images/conicet.png)
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Fecha de publicación:
02/2019
Editorial:
American Chemical Society
Revista:
Journal of Physical Chemistry B
ISSN:
1520-6106
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
P2X receptors are a group of trimeric cationic channels that are activated by adenosine 5′-triphosphate. They perform critical roles in the membranes of mammalian cells, and their improper functioning is associated with numerous diseases. Despite the vast amount of research devoted to them, several aspects of their operation are currently unclear, including the causes of their charge selectivity. We present the results of molecular dynamics simulation, which shed light on this issue for the case of P2X4 channels. We examined in detail the behavior of Na+ and Cl- ions inside the receptor. The examination reveals that charge discrimination occurs in two stages. First, cations bear precedence over anions to enter the extracellular vestibule. Then, cations at the extracellular vestibule are more likely to cross the pore than anions in an equivalent position. In this manner, a thorough but straightforward analysis of computational simulations suggests a stepwise mechanism, without a unique determinant factor.
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Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Citación
Pierdominici Sottile, Gustavo; Racigh, Vanesa Elizabeth; Ormazábal, Agustín; Palma, Juliana Isabel; Charge Discrimination in P2X4 Receptors Occurs in Two Consecutive Stages; American Chemical Society; Journal of Physical Chemistry B; 123; 5; 2-2019; 1017-1025
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