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dc.contributor.author
Lobmaier, Silvia M.
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Müller, A.
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Zelgert, C.
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Shen, C.
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Su, P. C.
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Schmidt, G.
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Haller, B.
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Berg, G.
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Fabre, B.
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Weyrich, J.
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Wu, H. T.
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Frasch, M. G.
dc.contributor.author
Antonelli, Marta Cristina
dc.date.available
2021-06-02T14:01:04Z
dc.date.issued
2019-11
dc.identifier.citation
Lobmaier, Silvia M.; Müller, A.; Zelgert, C.; Shen, C.; Su, P. C.; et al.; Fetal heart rate variability responsiveness to maternal stress, non-invasively detected from maternal transabdominal ECG; Springer Heidelberg; Archives Of Gynecology And Obstetrics.; 301; 2; 11-2019; 405-414
dc.identifier.issn
0932-0067
dc.identifier.uri
http://hdl.handle.net/11336/132993
dc.description.abstract
Purpose: Prenatal stress (PS) during pregnancy affects in utero and postnatal child brain development. Key systems affected are the hypothalamic-pituitary-adrenal axis and the autonomic nervous system (ANS). Maternal and fetal ANS activity can be gauged non-invasively from transabdominal electrocardiogram (taECG). We propose a novel approach to assess couplings between maternal (mHR) and fetal heart rate (fHR) as a new biomarker for PS based on bivariate phase-rectified signal averaging (BPRSA). We hypothesized that PS exerts lasting impact on fHR. Methods: Prospective case-control study matched for maternal age, parity and gestational age during the third trimester using the Cohen Perceived Stress Scale (PSS-10) questionnaire with PSS-10 over or equal 19 classified as stress group (SG). Women with PSS-10 < 19 served as control group (CG). Fetal electrocardiograms (fECG) were recorded by a taECG. Coupling between mHR and fHR was analyzed by BPRSA resulting in fetal stress index (FSI). Maternal hair cortisol, a memory of chronic stress exposure for 2-3 months, was measured at birth. Results: 538/1500 pregnant women returned the questionnaire, 55/538 (10.2%) mother-child pairs formed SG and were matched with 55/449 (12.2%) consecutive patients as CG. Maternal hair cortisol was 86.6 (48.0-169.2) versus 53.0 (34.4-105.9) pg/mg (p=0.029). At 36+5 weeks, FSI was significantly higher in fetuses of stressed mothers when compared to controls [0.43 (0.18-0.85) versus 0.00 (-0.49-0.18), p<0.001]. Conclusion: Prenatal maternal stress affects the coupling between maternal and fetal heart rate detectable non-invasively a month prior to birth. Lasting effects on neurodevelopment of affected offspring should be studied.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer Heidelberg
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ANS
dc.subject
BIVARIATE PHASE-RECTIFIED SIGNAL AVERAGING
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BPRSA
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FETAL AUTONOMIC NERVOUS SYSTEM
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FETAL HEART RATE
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FETAL STRESS INDEX
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FSI
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PRENATAL STRESS
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PS
dc.subject.classification
Biología del Desarrollo
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Fetal heart rate variability responsiveness to maternal stress, non-invasively detected from maternal transabdominal ECG
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-12-09T20:15:49Z
dc.journal.volume
301
dc.journal.number
2
dc.journal.pagination
405-414
dc.journal.pais
Alemania
dc.journal.ciudad
Heidelberg
dc.description.fil
Fil: Lobmaier, Silvia M.. Universitat Technical Zu Munich; Alemania
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Fil: Müller, A.. Universitat Technical Zu Munich; Alemania
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Fil: Zelgert, C.. Universitat Technical Zu Munich; Alemania
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Fil: Shen, C.. University of Duke; Estados Unidos
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Fil: Su, P. C.. University of Duke; Estados Unidos
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Fil: Schmidt, G.. Universitat Technical Zu Munich; Alemania
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Fil: Haller, B.. No especifíca;
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Fil: Berg, G.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
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Fil: Fabre, B.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Fisiopatología y Bioquímica Clínica; Argentina
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Fil: Weyrich, J.. Universitat Technical Zu Munich; Alemania
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Fil: Wu, H. T.. University of Duke; Estados Unidos
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Fil: Frasch, M. G.. University of Washington; Estados Unidos
dc.description.fil
Fil: Antonelli, Marta Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina
dc.journal.title
Archives Of Gynecology And Obstetrics.
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://link.springer.com/10.1007/s00404-019-05390-8
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s00404-019-05390-8
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