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dc.contributor.author
Rossi, Luis Francisco  
dc.contributor.author
Nottola, Stefania  
dc.contributor.author
Miglietta, Selenia  
dc.contributor.author
Macchiarelli, Guido  
dc.contributor.author
Luaces, Juan Pablo  
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Merico, Valeria  
dc.contributor.author
Merani, Maria Susana  
dc.contributor.author
Garagna, Silvia  
dc.contributor.author
Zuccotti, Maurizio  
dc.date.available
2021-06-02T12:24:57Z  
dc.date.issued
2019-11  
dc.identifier.citation
Rossi, Luis Francisco; Nottola, Stefania; Miglietta, Selenia; Macchiarelli, Guido; Luaces, Juan Pablo; et al.; Germ cell cysts, a fetal feature in mammals, are constitutively present in the adult armadillo; Wiley-liss, div John Wiley & Sons Inc.; Molecular Reproduction and Development; 87; 1; 11-2019; 91-101  
dc.identifier.issn
1040-452X  
dc.identifier.uri
http://hdl.handle.net/11336/132991  
dc.description.abstract
Formation and subsequent break down of ovarian germ cell (GC) cysts is a key and an evolutionary-conserved developmental event, described in phylogenetically diverse species of invertebrates and vertebrates. In mammals, cyst break down (CBD) ends at the time of, or soon after, birth with the formation of primordial follicles enclosing single oocytes, which constitute the sole reservoir of gametes available through the whole female's reproductive life. In this study, we challenge this paradigm demonstrating the constitutive presence of a large number of cysts, enclosing two-thirty GCs, in the ovary of the adult armadillo Chaetophractus villosus, belonging to the superorder Xenarthra, one of the earliest offshoots among placentals. We also describe that (a) GCs enclosed within cysts are connected by intercellular bridges—intercellular bridges—markers of their clonal origin; (b) CBD occurs through four main phases, ending with primordial follicles containing single oocytes; (c) GCs encompass meiotic prophase I stages, from leptotene to diplotene; (d) seasonal variations in the number of GCs enclosed within cysts, suggesting the presence of a GC multiplying activity. The armadillo C. villosus''s ovary emerges as an extraordinary resource to investigate folliculogenesis and to explore the evolutionary past of the mammalian ovary.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Wiley-liss, div John Wiley & Sons Inc.  
dc.rights
info:eu-repo/semantics/restrictedAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
ARMADILLO  
dc.subject
FOLLICULOGENESIS  
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GERM CELL CYSTS  
dc.subject
OOGENESIS  
dc.subject
XENARTHRA  
dc.subject.classification
Biología Reproductiva  
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Ciencias Biológicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
Germ cell cysts, a fetal feature in mammals, are constitutively present in the adult armadillo  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2021-04-28T21:37:28Z  
dc.journal.volume
87  
dc.journal.number
1  
dc.journal.pagination
91-101  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
New York  
dc.description.fil
Fil: Rossi, Luis Francisco. Universidad de Buenos Aires. Facultad de Medicina. Laboratorio de Biología Cromosómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina  
dc.description.fil
Fil: Nottola, Stefania. Università degli Studi di Roma "La Sapienza"; Italia  
dc.description.fil
Fil: Miglietta, Selenia. Università degli Studi di Roma "La Sapienza"; Italia  
dc.description.fil
Fil: Macchiarelli, Guido. Universita degli Studi dell'Aquila; Italia  
dc.description.fil
Fil: Luaces, Juan Pablo. Universidad de Buenos Aires. Facultad de Medicina. Laboratorio de Biología Cromosómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina  
dc.description.fil
Fil: Merico, Valeria. Universita Degli Studi Di Pavia; Italia  
dc.description.fil
Fil: Merani, Maria Susana. Universidad de Buenos Aires. Facultad de Medicina. Laboratorio de Biología Cromosómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina  
dc.description.fil
Fil: Garagna, Silvia. Universita Degli Studi Di Pavia; Italia  
dc.description.fil
Fil: Zuccotti, Maurizio. Universita Degli Studi Di Pavia; Italia  
dc.journal.title
Molecular Reproduction and Development  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/mrd.23296  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/mrd.23296