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dc.contributor.author
Rulli, Susana Beatriz
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dc.contributor.author
Ahtiainen, Petteri
dc.contributor.author
Poutanen, Matti
dc.contributor.author
Hutaniemi, Ilpo T.
dc.date.available
2021-05-29T01:23:40Z
dc.date.issued
2009
dc.identifier.citation
Rulli, Susana Beatriz; Ahtiainen, Petteri; Poutanen, Matti; Hutaniemi, Ilpo T.; Mechanisms of multiple forms of tumorigenesis in LH/hCG overexpressing transgenic mice; Narosa Publishing; 2009; 80-89
dc.identifier.isbn
978-81-7319-932-5
dc.identifier.uri
http://hdl.handle.net/11336/132806
dc.description.abstract
The two gonadotrophins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) are produced by the pituitary gland as heterodimers composed of a common a-subunit and the hormone- specific b-subunit. They have a key role in ovarian and testicular functions by acting through binding to their specific seven-transmembrane domain G-protein coupled receptors (Burger et al., 2004). In the gonads, LH receptors are located in testicular Leydig cells and in ovarian theca, granulosa and luteal cells (Ascoli et al., 2002). FSH receptors are expressed in testicular Sertoli cells and in granulosa cells of the ovary (Simoni et al., 1997). Although primarily expressed in gonads, LH receptors are also found in numerous extragonadal tissues (Rao, 2001; Filicori et al., 2005). However, their physiological significance is still unclear (Pakarainen et al., 2007). The placental analogue of LH, human chorionic gonadotrophin (hCG) interacts with the same LH/hCG receptor as LH, and functions as an LH agonist with a longer half-life and higher biopotency than its pituitary counterpart (Jameson and Hollenberg,1993).
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Narosa Publishing
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
TUMOR
dc.subject
HUMAN CHORIONIC GONADOTROPIN
dc.subject
TRANSGENIC
dc.subject.classification
Fisiología
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Mechanisms of multiple forms of tumorigenesis in LH/hCG overexpressing transgenic mice
dc.type
info:eu-repo/semantics/publishedVersion
dc.type
info:eu-repo/semantics/bookPart
dc.type
info:ar-repo/semantics/parte de libro
dc.date.updated
2020-08-24T18:08:38Z
dc.journal.pagination
80-89
dc.journal.pais
India
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dc.journal.ciudad
New Delhi
dc.description.fil
Fil: Rulli, Susana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Ahtiainen, Petteri. University of Turku; Finlandia
dc.description.fil
Fil: Poutanen, Matti. University of Turku; Finlandia
dc.description.fil
Fil: Hutaniemi, Ilpo T.. University of Turku; Finlandia. Imperial College. London Institute Of Medical Sciences.;
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.narosa.com/books_display.asp?catgcode=978-81-7319-932-5
dc.conicet.paginas
248
dc.source.titulo
Treatment of advanced stage cancers: current status and emerging frontiers
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