Artículo
Fish oil diet effects on alveolar bone loss, in hypercholesterolemic rats
Antona, María Eugenia; Ramos, Cecilia; Stranges, Andrea; Ferreira Monteiro, Andrea Gloria; Gonzales Chaves, María Macarena; Mandalunis, Patricia; Zago, Valeria
; Friedman, Silvia María; Macri, Elisa Vanesa
Fecha de publicación:
02/2020
Editorial:
Pergamon-Elsevier Science Ltd
Revista:
Archives of Oral Biology
ISSN:
0003-9969
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
This study evaluated the effects of replacing a saturated fat diet by n-3 polyunsaturated fatty acids (n-3PUFA), on alveolar bone loss in hypercholesterolemic rats with experimental periodontitis (PD). Methods: Eight week old Wistar rats were assigned according to dietary intake. Control group (C, n = 15) fed a commercial diet throughout the experiment. Atherogenic group (AT, n = 30) fed AT diet for 3 weeks; thereafter, AT was randomized to receive either a n-3PUFA (n = 15) or to continue with AT (n = 15) diet. Subsequently, PD was induced in all groups by unilateral ligature (L) of the first molar (M1) of the left mandible, non-ligated contralateral molars served as controls. After every week of PD induction, 5 rats per group were euthanized. Serum was collected for lipids assays and hemi-mandibles were subjected to histomorphometric (% upper and lower interradicular bone volume and periodontal ligament height, hPDL) and radiographic analyses (periodontal bone support, PBS, in ligated teeth, between M1-M2). Results: Rats fed n-3PUFA diet rapidly induced a significant reduction in the serum lipids (p < 0.001). In all rats the ligated teeth showed a greater bone loss as compared with the unligated molars. At the end of the experiment the AT + L was the worst in % lower bone volume (p < 0.01), hPDL and PBS (p < 0.05). In contrast, rats fed n-3PUFA + L was similar to those rats fed C diet (p > 0.05). Conclusion: Alveolar bone and dyslipidemia improved by substituting saturated fat intake for a n-3PUFA rich diet, in hypercholesterolemic rats with PD.
Palabras clave:
ALVEOLAR BONE LOSS
,
FISH OIL
,
HYPERCHOLESTEROLEMIA
,
PERIODONTITIS
,
RAT
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Antona, María Eugenia; Ramos, Cecilia; Stranges, Andrea; Ferreira Monteiro, Andrea Gloria; Gonzales Chaves, María Macarena; et al.; Fish oil diet effects on alveolar bone loss, in hypercholesterolemic rats; Pergamon-Elsevier Science Ltd; Archives of Oral Biology; 109; 2-2020; 1-9
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