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dc.contributor.author
Hernandez, Jose A.
dc.contributor.author
Curatti, Leonardo
dc.contributor.author
Aznar, Constantino P.
dc.contributor.author
Perova, Zinaida
dc.contributor.author
Britt, R. David
dc.contributor.author
Rubio, Luis M.
dc.date.available
2021-05-21T15:27:03Z
dc.date.issued
2008-08-19
dc.identifier.citation
Hernandez, Jose A.; Curatti, Leonardo; Aznar, Constantino P.; Perova, Zinaida; Britt, R. David; et al.; Metal trafficking for nitrogen fixation: NifQ donates molybdenum to NifEN/NifH for the biosynthesis of the nitrogenase FeMo-cofactor; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 105; 33; 19-8-2008; 11679-11684
dc.identifier.issn
0027-8424
dc.identifier.uri
http://hdl.handle.net/11336/132499
dc.description.abstract
The molybdenum nitrogenase, present in a diverse group of bacteria and archea, is the major contributor to biological nitrogen fixation. The nitrogenase active site contains an iron-molybdenum cofactor (FeMo-co) composed of 7Fe, 9S, 1Mo, one unidentified light atom, and homocitrate. The nifQ gene was known to be involved in the incorporation of molybdenum into nitrogenase. Here we show direct biochemical evidence for the role of NifQ in FeMo-co biosynthesis. As-isolated NifQ was found to carry a molybdenum-iron-sulfur cluster that serves as a specific molybdenum donor for FeMo-co biosynthesis. Purified NifQ supported in vitro FeMo-co synthesis in the absence of an additional molybdenum source. The mobilization of molybdenum from NifQ required the simultaneous participation of NifH and NifEN in the in vitro FeMo-co synthesis assay, suggesting that NifQ would be the physiological molybdenum donor to a hypothetical NifEN/NifH complex.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
National Academy of Sciences
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
AZOTOBACTER VINELANDII
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IRON-SULFUR CLUSTER
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NIF
dc.subject.classification
Biología Celular, Microbiología
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Metal trafficking for nitrogen fixation: NifQ donates molybdenum to NifEN/NifH for the biosynthesis of the nitrogenase FeMo-cofactor
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-04-28T21:45:00Z
dc.identifier.eissn
1091-6490
dc.journal.volume
105
dc.journal.number
33
dc.journal.pagination
11679-11684
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Washington DC
dc.description.fil
Fil: Hernandez, Jose A.. University of California; Estados Unidos
dc.description.fil
Fil: Curatti, Leonardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario; Argentina
dc.description.fil
Fil: Aznar, Constantino P.. University of California; Estados Unidos
dc.description.fil
Fil: Perova, Zinaida. University of California; Estados Unidos
dc.description.fil
Fil: Britt, R. David. University of California; Estados Unidos
dc.description.fil
Fil: Rubio, Luis M.. University of California; Estados Unidos
dc.journal.title
Proceedings of the National Academy of Sciences of The United States of America
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1073/pnas.0803576105
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.pnas.org/content/105/33/11679
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