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dc.contributor.author Ballarre, Josefina
dc.contributor.author Manjubala, Inderchand
dc.contributor.author Schreiner, Wido H.
dc.contributor.author Orellano, Juan Carlos
dc.contributor.author Fratzl, Peter
dc.contributor.author Cere, Silvia
dc.date.available 2017-02-21T15:06:30Z
dc.date.issued 2009-10-14
dc.identifier.citation Ballarre, Josefina; Manjubala, Inderchand; Schreiner, Wido H.; Orellano, Juan Carlos; Fratzl, Peter; et al.; Improving the osteointegration and bone–implant interface by incorporation of bioactive particles in sol–gel coatings of stainless steel implants; Elsevier; Acta Biomaterialia; 6; 4; 14-10-2009; 1742-7061
dc.identifier.issn 1742-7061
dc.identifier.uri http://hdl.handle.net/11336/13240
dc.description.abstract In this study, we report a hybrid organic–inorganic TEOS–MTES (tetraethylorthosilicate–methyltriethoxysilane) sol–gel-made coating as a potential solution to improve the in vivo performance of AISI 316L stainless steel, which is used as permanent bone implant material. These coatings act as barriers for ion migration, promoting the bioactivity of the implant surface. The addition of SiO2 colloidal particles to the TEOS–MTES sol (10 or 30 mol.%) leads to thicker films and also acts as a film reinforcement. Also, the addition of bioactive glass–ceramic particles is considered responsible for enhancing osseointegration. In vitro assays for bioactivity in simulated body fluid showed the presence of crystalline hydroxyapatite (HA) crystals on the surface of the double coating with 10 mol.% SiO2 samples on stainless steel after 30 days of immersion. The HA crystal lattice parameters are slightly different from stoichiometric HA. In vivo implantation experiments were carried out in a rat model to observe the osteointegration of the coated implants. The coatings promote the development of newly formed bone in the periphery of the implant, in both the remodellation zone and the marrow zone. The quality of the newly formed bone was assessed for mechanical and structural integrity by nanoindentation and small-angle X-ray scattering experiments. The different amount of colloidal silica present in the inner layer of the coating slightly affects the material quality of the newly formed bone but the nanoindentation results reveal that the lower amount of silica in the coating leads to mechanical properties similar to cortical bone.
dc.format application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject COATINGS
dc.subject SURGICAL GRADE STAINLESS STEEL
dc.subject HYDROXYAPATITE
dc.subject NEWLY FORMED BONE
dc.subject SAXS
dc.subject.classification Recubrimientos y Películas
dc.subject.classification Ingeniería de los Materiales
dc.subject.classification INGENIERÍAS Y TECNOLOGÍAS
dc.subject.classification Físico-Química, Ciencia de los Polímeros, Electroquímica
dc.subject.classification Ciencias Químicas
dc.subject.classification CIENCIAS NATURALES Y EXACTAS
dc.title Improving the osteointegration and bone–implant interface by incorporation of bioactive particles in sol–gel coatings of stainless steel implants
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2017-02-06T14:31:17Z
dc.journal.volume 6
dc.journal.number 4
dc.journal.pagination 1742-7061
dc.journal.pais Países Bajos
dc.journal.ciudad Amsterdam
dc.description.fil Fil: Ballarre, Josefina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mar del Plata. Instituto de Investigación en Ciencia y Tecnología de Materiales (i); Argentina. Universidad Nacional de Mar del Plata. Facultad de Ingeniería; Argentina
dc.description.fil Fil: Manjubala, Inderchand. Max Planck Institute of Colloids and Interfaces; Alemania
dc.description.fil Fil: Schreiner, Wido H.. Universidade Federal Do Parana; Brasil
dc.description.fil Fil: Orellano, Juan Carlos. Hospital Interzonal General de Agudos ‘‘Oscar Alende”; Argentina
dc.description.fil Fil: Fratzl, Peter. Max Planck Institute of Colloids and Interfaces; Alemania
dc.description.fil Fil: Cere, Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mar del Plata. Instituto de Investigación en Ciencia y Tecnología de Materiales (i); Argentina. Universidad Nacional de Mar del Plata. Facultad de Ingeniería; Argentina
dc.journal.title Acta Biomaterialia
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1742706109004504
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.actbio.2009.10.015


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    Articulos de INST.DE INV.EN CIENCIA Y TECNOL.MATERIALES (I)

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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)