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dc.contributor.author
Ballarre, Josefina
dc.contributor.author
Manjubala, Inderchand
dc.contributor.author
Schreiner, Wido H.
dc.contributor.author
Orellano, Juan Carlos
dc.contributor.author
Fratzl, Peter
dc.contributor.author
Cere, Silvia
dc.date.available
2017-02-21T15:06:30Z
dc.date.issued
2009-10-14
dc.identifier.citation
Ballarre, Josefina; Manjubala, Inderchand; Schreiner, Wido H.; Orellano, Juan Carlos; Fratzl, Peter; et al.; Improving the osteointegration and bone–implant interface by incorporation of bioactive particles in sol–gel coatings of stainless steel implants; Elsevier; Acta Biomaterialia; 6; 4; 14-10-2009; 1742-7061
dc.identifier.issn
1742-7061
dc.identifier.uri
http://hdl.handle.net/11336/13240
dc.description.abstract
In this study, we report a hybrid organic–inorganic TEOS–MTES (tetraethylorthosilicate–methyltriethoxysilane) sol–gel-made coating as a potential solution to improve the in vivo performance of AISI 316L stainless steel, which is used as permanent bone implant material. These coatings act as barriers for ion migration, promoting the bioactivity of the implant surface. The addition of SiO2 colloidal particles to the TEOS–MTES sol (10 or 30 mol.%) leads to thicker films and also acts as a film reinforcement. Also, the addition of bioactive glass–ceramic particles is considered responsible for enhancing osseointegration. In vitro assays for bioactivity in simulated body fluid showed the presence of crystalline hydroxyapatite (HA) crystals on the surface of the double coating with 10 mol.% SiO2 samples on stainless steel after 30 days of immersion. The HA crystal lattice parameters are slightly different from stoichiometric HA. In vivo implantation experiments were carried out in a rat model to observe the osteointegration of the coated implants. The coatings promote the development of newly formed bone in the periphery of the implant, in both the remodellation zone and the marrow zone. The quality of the newly formed bone was assessed for mechanical and structural integrity by nanoindentation and small-angle X-ray scattering experiments. The different amount of colloidal silica present in the inner layer of the coating slightly affects the material quality of the newly formed bone but the nanoindentation results reveal that the lower amount of silica in the coating leads to mechanical properties similar to cortical bone.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Coatings
dc.subject
Surgical Grade Stainless Steel
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Hydroxyapatite
dc.subject
Newly Formed Bone
dc.subject
Saxs
dc.subject.classification
Recubrimientos y Películas
dc.subject.classification
Ingeniería de los Materiales
dc.subject.classification
INGENIERÍAS Y TECNOLOGÍAS
dc.subject.classification
Físico-Química, Ciencia de los Polímeros, Electroquímica
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Ciencias Químicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Improving the osteointegration and bone–implant interface by incorporation of bioactive particles in sol–gel coatings of stainless steel implants
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-02-06T14:31:17Z
dc.journal.volume
6
dc.journal.number
4
dc.journal.pagination
1742-7061
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Ballarre, Josefina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mar del Plata. Instituto de Investigación en Ciencia y Tecnología de Materiales (i); Argentina. Universidad Nacional de Mar del Plata. Facultad de Ingeniería; Argentina
dc.description.fil
Fil: Manjubala, Inderchand. Max Planck Institute of Colloids and Interfaces; Alemania
dc.description.fil
Fil: Schreiner, Wido H.. Universidade Federal Do Parana; Brasil
dc.description.fil
Fil: Orellano, Juan Carlos. Hospital Interzonal General de Agudos ‘‘Oscar Alende”; Argentina
dc.description.fil
Fil: Fratzl, Peter. Max Planck Institute of Colloids and Interfaces; Alemania
dc.description.fil
Fil: Cere, Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mar del Plata. Instituto de Investigación en Ciencia y Tecnología de Materiales (i); Argentina. Universidad Nacional de Mar del Plata. Facultad de Ingeniería; Argentina
dc.journal.title
Acta Biomaterialia
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1742706109004504
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.actbio.2009.10.015


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