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dc.contributor.author
Albarracín Orio, Andrea Georgina
dc.contributor.author
Cortes, Paulo
dc.contributor.author
Tregnaghi, Miguel
dc.contributor.author
Piñas, German Eduardo
dc.contributor.author
Echenique, Jose Ricardo
dc.contributor.author
Yudowski, Silvia
dc.contributor.author
Carvajal, Lydia
dc.contributor.author
Culasso, Catalina
dc.contributor.author
Nobile, Carmen Beatriz
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Figueroa, Myriam Haydee
dc.contributor.author
Lopardo, Horacio
dc.contributor.author
Hernández, Claudia
dc.contributor.author
Regueira, Mabel
dc.date.available
2021-05-20T15:23:53Z
dc.date.issued
2008-12
dc.identifier.citation
Albarracín Orio, Andrea Georgina; Cortes, Paulo; Tregnaghi, Miguel; Piñas, German Eduardo; Echenique, Jose Ricardo; et al.; A new serotype 14 variant of the pneumococcal Spain9V-3 international clone detected in the central region of Argentina; Society for General Microbiology; Journal of Medical Microbiology; 57; 8; 12-2008; 992-999
dc.identifier.issn
0022-2615
dc.identifier.uri
http://hdl.handle.net/11336/132363
dc.description.abstract
The penicillin-resistant Spain9V-3 clone of Streptococcus pneumoniae is widespread and presents different serotype variants originating from recombination of the capsular genes. In this work, the genetic relatedness of 29 invasive pneumococci isolated from the central region of Argentina (Cordoba, Buenos Aires, Santa Fe and La Pampa provinces) was assessed by multilocus sequence typing (MLST). All of the penicillin-non-susceptible isolates studied (21/29) belonged to a serotype 14 variant of the Spain 9V-3 clone. This clone was predominant, suggesting that it was responsible for the penicillin resistance spread in this region. Interestingly, this serotype 14 variant (named Cordoba S14V) could be differentiated from the European one by its pbp1a gene, suggesting a different recombinational replacement of the capsular genes. The putative recombination sites were analysed, resulting in the proximal crossover point being clearly localized in the spr0309 gene, with the distal site restricted to the recU gene, confirming a different recombination event. Analysis of the dexB, cpsB, aliA and pbp1a genes from these strains showed a high similarity with the corresponding genes of the Spain14-5 clone, suggesting that the capsular genes were provided by this international clone. Analysis of the genetic polymorphisms of the pbp1a (nt 1473-1922) and spr0309 (nt 1-790) genes is proposed as an epidemiological tool to help recognize the Cordoba S14V of the Spain9V-3 clone. On the other hand, BOX-repeat-based PCR and MLST analyses of serotype 14 strains revealed a divergent epidemiology of the Cordoba S14V, suggesting a non-recent dissemination in the paediatric population. It is suggested that this molecular epidemiology work will be a reference for monitoring the evolution of S14Vs of Spain9V-3, the emergence of new clones and the impact of pneumococcal vaccination programmes in Argentina.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Society for General Microbiology
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
STREPTOCOCCUS PNEUMONIAE
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MOLECULAR EPIDEMIOLOGY
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PENICILLIN RESISTANCE
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CAPSULAR GENES
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Biología Celular, Microbiología
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
A new serotype 14 variant of the pneumococcal Spain9V-3 international clone detected in the central region of Argentina
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-04-23T17:16:55Z
dc.identifier.eissn
1473-5644
dc.journal.volume
57
dc.journal.number
8
dc.journal.pagination
992-999
dc.journal.pais
Reino Unido
dc.journal.ciudad
London
dc.description.fil
Fil: Albarracín Orio, Andrea Georgina. Universidad Católica de Córdoba. Instituto de Investigaciones en Recursos Naturales y Sustentabilidad José Sanchez Labrador S. J. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Recursos Naturales y Sustentabilidad José Sanchez Labrador S. J.; Argentina
dc.description.fil
Fil: Cortes, Paulo. Hospital Pediátrico del Niño Jesús; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
dc.description.fil
Fil: Tregnaghi, Miguel. Centro de Desarrollo de Proyectos Avanzados en Pediatria; Argentina
dc.description.fil
Fil: Piñas, German Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
dc.description.fil
Fil: Echenique, Jose Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
dc.description.fil
Fil: Yudowski, Silvia. Centro de Desarrollo de Proyectos Avanzados en Pediatria; Argentina
dc.description.fil
Fil: Carvajal, Lydia. Centro de Desarrollo de Proyectos Avanzados en Pediatria; Argentina
dc.description.fil
Fil: Culasso, Catalina. Centro de Desarrollo de Proyectos Avanzados en Pediatria; Argentina
dc.description.fil
Fil: Nobile, Carmen Beatriz. Centro de Desarrollo de Proyectos Avanzados en Pediatria; Argentina
dc.description.fil
Fil: Figueroa, Myriam Haydee. Centro de Desarrollo de Proyectos Avanzados en Pediatria; Argentina
dc.description.fil
Fil: Lopardo, Horacio. Fundacion Hospital de Pediatria Professor Dr. Juan P. Garrahan; Argentina
dc.description.fil
Fil: Hernández, Claudia. Fundacion Hospital de Pediatria Professor Dr. Juan P. Garrahan; Argentina
dc.description.fil
Fil: Regueira, Mabel. Instituto Nacional de Enfermedades Infecciosas; Argentina
dc.journal.title
Journal of Medical Microbiology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1099/jmm.0.2008/000505-0
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.2008/000505-0
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