Mostrar el registro sencillo del ítem

dc.contributor.author
Albarracín Orio, Andrea Georgina  
dc.contributor.author
Cortes, Paulo  
dc.contributor.author
Tregnaghi, Miguel  
dc.contributor.author
Piñas, German Eduardo  
dc.contributor.author
Echenique, Jose Ricardo  
dc.contributor.author
Yudowski, Silvia  
dc.contributor.author
Carvajal, Lydia  
dc.contributor.author
Culasso, Catalina  
dc.contributor.author
Nobile, Carmen Beatriz  
dc.contributor.author
Figueroa, Myriam Haydee  
dc.contributor.author
Lopardo, Horacio  
dc.contributor.author
Hernández, Claudia  
dc.contributor.author
Regueira, Mabel  
dc.date.available
2021-05-20T15:23:53Z  
dc.date.issued
2008-12  
dc.identifier.citation
Albarracín Orio, Andrea Georgina; Cortes, Paulo; Tregnaghi, Miguel; Piñas, German Eduardo; Echenique, Jose Ricardo; et al.; A new serotype 14 variant of the pneumococcal Spain9V-3 international clone detected in the central region of Argentina; Society for General Microbiology; Journal of Medical Microbiology; 57; 8; 12-2008; 992-999  
dc.identifier.issn
0022-2615  
dc.identifier.uri
http://hdl.handle.net/11336/132363  
dc.description.abstract
The penicillin-resistant Spain9V-3 clone of Streptococcus pneumoniae is widespread and presents different serotype variants originating from recombination of the capsular genes. In this work, the genetic relatedness of 29 invasive pneumococci isolated from the central region of Argentina (Cordoba, Buenos Aires, Santa Fe and La Pampa provinces) was assessed by multilocus sequence typing (MLST). All of the penicillin-non-susceptible isolates studied (21/29) belonged to a serotype 14 variant of the Spain 9V-3 clone. This clone was predominant, suggesting that it was responsible for the penicillin resistance spread in this region. Interestingly, this serotype 14 variant (named Cordoba S14V) could be differentiated from the European one by its pbp1a gene, suggesting a different recombinational replacement of the capsular genes. The putative recombination sites were analysed, resulting in the proximal crossover point being clearly localized in the spr0309 gene, with the distal site restricted to the recU gene, confirming a different recombination event. Analysis of the dexB, cpsB, aliA and pbp1a genes from these strains showed a high similarity with the corresponding genes of the Spain14-5 clone, suggesting that the capsular genes were provided by this international clone. Analysis of the genetic polymorphisms of the pbp1a (nt 1473-1922) and spr0309 (nt 1-790) genes is proposed as an epidemiological tool to help recognize the Cordoba S14V of the Spain9V-3 clone. On the other hand, BOX-repeat-based PCR and MLST analyses of serotype 14 strains revealed a divergent epidemiology of the Cordoba S14V, suggesting a non-recent dissemination in the paediatric population. It is suggested that this molecular epidemiology work will be a reference for monitoring the evolution of S14Vs of Spain9V-3, the emergence of new clones and the impact of pneumococcal vaccination programmes in Argentina.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Society for General Microbiology  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
STREPTOCOCCUS PNEUMONIAE  
dc.subject
MOLECULAR EPIDEMIOLOGY  
dc.subject
PENICILLIN RESISTANCE  
dc.subject
CAPSULAR GENES  
dc.subject.classification
Biología Celular, Microbiología  
dc.subject.classification
Ciencias Biológicas  
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS  
dc.title
A new serotype 14 variant of the pneumococcal Spain9V-3 international clone detected in the central region of Argentina  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2021-04-23T17:16:55Z  
dc.identifier.eissn
1473-5644  
dc.journal.volume
57  
dc.journal.number
8  
dc.journal.pagination
992-999  
dc.journal.pais
Reino Unido  
dc.journal.ciudad
London  
dc.description.fil
Fil: Albarracín Orio, Andrea Georgina. Universidad Católica de Córdoba. Instituto de Investigaciones en Recursos Naturales y Sustentabilidad José Sanchez Labrador S. J. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Recursos Naturales y Sustentabilidad José Sanchez Labrador S. J.; Argentina  
dc.description.fil
Fil: Cortes, Paulo. Hospital Pediátrico del Niño Jesús; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina  
dc.description.fil
Fil: Tregnaghi, Miguel. Centro de Desarrollo de Proyectos Avanzados en Pediatria; Argentina  
dc.description.fil
Fil: Piñas, German Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina  
dc.description.fil
Fil: Echenique, Jose Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina  
dc.description.fil
Fil: Yudowski, Silvia. Centro de Desarrollo de Proyectos Avanzados en Pediatria; Argentina  
dc.description.fil
Fil: Carvajal, Lydia. Centro de Desarrollo de Proyectos Avanzados en Pediatria; Argentina  
dc.description.fil
Fil: Culasso, Catalina. Centro de Desarrollo de Proyectos Avanzados en Pediatria; Argentina  
dc.description.fil
Fil: Nobile, Carmen Beatriz. Centro de Desarrollo de Proyectos Avanzados en Pediatria; Argentina  
dc.description.fil
Fil: Figueroa, Myriam Haydee. Centro de Desarrollo de Proyectos Avanzados en Pediatria; Argentina  
dc.description.fil
Fil: Lopardo, Horacio. Fundacion Hospital de Pediatria Professor Dr. Juan P. Garrahan; Argentina  
dc.description.fil
Fil: Hernández, Claudia. Fundacion Hospital de Pediatria Professor Dr. Juan P. Garrahan; Argentina  
dc.description.fil
Fil: Regueira, Mabel. Instituto Nacional de Enfermedades Infecciosas; Argentina  
dc.journal.title
Journal of Medical Microbiology  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1099/jmm.0.2008/000505-0  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.2008/000505-0