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dc.contributor.author
De Oliveira Alvares, Lucaa  
dc.contributor.author
Engelke, Douglas Senna  
dc.contributor.author
Diehl, Felipe  
dc.contributor.author
Scheffer-Teixeira, Robson  
dc.contributor.author
Haubrich, Josué  
dc.contributor.author
De Freitas Cassini, Lindsey  
dc.contributor.author
Molina, Víctor Alejandro  
dc.contributor.author
Quillfeldt, Jorge Alberto  
dc.date.available
2021-05-18T19:29:29Z  
dc.date.issued
2010-03  
dc.identifier.citation
De Oliveira Alvares, Lucaa; Engelke, Douglas Senna; Diehl, Felipe; Scheffer-Teixeira, Robson; Haubrich, Josué; et al.; Stress response recruits the hippocampal endocannabinoid system for the modulation of fear memory; Cold Spring Harbor Laboratory Press; Learning & Memory (Cold Spring Harbor, N.Y.); 17; 4; 3-2010; 202-209  
dc.identifier.issn
1072-0502  
dc.identifier.uri
http://hdl.handle.net/11336/132240  
dc.description.abstract
The modulation of memory processes is one of the several functions of the endocannabinoid system (ECS) in the brain, with CB1 receptors highly expressed in areas such as the dorsal hippocampus. Experimental evidence suggested an important role of the ECS in aversively motivated memories. Similarly, glucocorticoids released in response to stress exposure also modulates memory formation, and both stress and dexamethasone activate the ECS. Here, we investigate the interaction between the ECS and glucocorticoids in the hippocampus in the modulation of fear memory consolidation. Two protocols with different shock intensities were used in order to control the level of aversiveness. Local infusion of AM251 into the hippocampus immediately after training was amnestic in the strong, but not in the weak protocol. Moreover, AM251 was amnestic in animals stressed 0, but not 30-min prior to the weak protocol, reverting the stress-induced facilitatory effect. Finally, intrahippocampal AM251 infusion reduced memory in animals that received dexamethasone immediately, but not 30 min before training. These results are (1) consistent with the view that the dorsal hippocampus ECS is activated on demand, in a rapid and short-lived fashion in order to modulate the consolidation of an aversive memory, and (2) show that this recruitment seems to be mediated by glucocorticoids, either in the hippocampus or in other brain regions functionally associated with the hippocampus. © 2010 Cold Spring Harbor Laboratory Press.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Cold Spring Harbor Laboratory Press  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
STRESS  
dc.subject
ENDOCANABINOID SYSTEM  
dc.subject
FEAR MEMORY  
dc.subject
HIPPOCAMPUS  
dc.subject.classification
Otras Ciencias de la Salud  
dc.subject.classification
Ciencias de la Salud  
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Stress response recruits the hippocampal endocannabinoid system for the modulation of fear memory  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2021-04-23T17:23:55Z  
dc.identifier.eissn
1549-5485  
dc.journal.volume
17  
dc.journal.number
4  
dc.journal.pagination
202-209  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
New York  
dc.description.fil
Fil: De Oliveira Alvares, Lucaa. Universidade Federal do Rio Grande do Sul; Brasil  
dc.description.fil
Fil: Engelke, Douglas Senna. Universidade Federal do Rio Grande do Sul; Brasil  
dc.description.fil
Fil: Diehl, Felipe. Universidade Federal do Rio Grande do Sul; Brasil  
dc.description.fil
Fil: Scheffer-Teixeira, Robson. Universidade Federal do Rio Grande do Sul; Brasil  
dc.description.fil
Fil: Haubrich, Josué. Universidade Federal do Rio Grande do Sul; Brasil  
dc.description.fil
Fil: De Freitas Cassini, Lindsey. Universidade Federal do Rio Grande do Sul; Brasil  
dc.description.fil
Fil: Molina, Víctor Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina  
dc.description.fil
Fil: Quillfeldt, Jorge Alberto. Universidade Federal do Rio Grande do Sul; Brasil  
dc.journal.title
Learning & Memory (Cold Spring Harbor, N.Y.)  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://learnmem.cshlp.org/content/17/4/202  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1101/lm.1721010