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dc.contributor.author
Cuervo, Henar
dc.contributor.author
Pineda, Miguel A.
dc.contributor.author
Aoki, Maria del Pilar
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dc.contributor.author
Gea, Susana
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dc.contributor.author
Fresno, Manuel
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dc.contributor.author
Gironès, Núria
dc.date.available
2021-05-17T20:11:32Z
dc.date.issued
2008-06
dc.identifier.citation
Cuervo, Henar; Pineda, Miguel A.; Aoki, Maria del Pilar; Gea, Susana; Fresno, Manuel; et al.; Inducible nitric oxide synthase and arginase expression in heart tissue during acute Trypanosoma cruzi infection in mice: Arginase I is expressed in infiltrating CD68+ macrophages; University of Chicago Press; Journal Of Infectious Diseases; 179; 12; 6-2008; 1772-1782
dc.identifier.issn
0022-1899
dc.identifier.uri
http://hdl.handle.net/11336/132181
dc.description.abstract
In Chagas disease, which is caused by Trypanosoma cruzi, macrophages and cardiomyocytes are the main targets of infection. Classical activation of macrophages during infection is protective, whereas alternative activation of macrophages is involved in the survival of host cells and parasites. We studied the expression of inducible nitric oxide synthase (iNOS) and arginase as markers of classical and alternative activation, respectively, in heart tissue during in vivo infection of BALB/c and C57BL/6 mice. We found that expression of arginase I and II, as well as that of ornithine decarboxylase, was much higher in BALB/c mice than in C57BL/6 mice and that it was associated with the parasite burden in heart tissue. iNOS and arginase II were expressed by cardiomyocytes. Interestingly, heart-infiltrated CD68+ macrophages were the major cell type expressing arginase I. T helper (Th) 1 and Th2 cytokines were expressed in heart tissue in both infected mouse strains; however, at the peak of parasite infection, the balance between Th1 and Th2 predominantly favored Th1 in C57BL/6 mice and Th2 in BALB/c mice. The results of the present study suggest that Th2 cytokines induce arginase expression, which may influence host and parasite cell survival but which might also down-regulate the counterproductive effects triggered by iNOS in the heart during infection.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
University of Chicago Press
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject.classification
Otras Ciencias Médicas
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dc.subject.classification
Otras Ciencias Médicas
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Inducible nitric oxide synthase and arginase expression in heart tissue during acute Trypanosoma cruzi infection in mice: Arginase I is expressed in infiltrating CD68+ macrophages
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-04-23T17:16:53Z
dc.identifier.eissn
1537-6613
dc.journal.volume
179
dc.journal.number
12
dc.journal.pagination
1772-1782
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Chicago
dc.description.fil
Fil: Cuervo, Henar. Universidad Autónoma de Madrid; España
dc.description.fil
Fil: Pineda, Miguel A.. Universidad Autónoma de Madrid; España
dc.description.fil
Fil: Aoki, Maria del Pilar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
dc.description.fil
Fil: Gea, Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
dc.description.fil
Fil: Fresno, Manuel. Universidad Autónoma de Madrid; España
dc.description.fil
Fil: Gironès, Núria. Universidad Autónoma de Madrid; España
dc.journal.title
Journal Of Infectious Diseases
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1086/529527
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/jid/article/197/12/1772/867411
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