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dc.contributor.author
Gonzalez, Jimena Soledad
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dc.contributor.author
Alvarez, Vera Alejandra
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dc.contributor.other
Wythers, Maryann C.
dc.date.available
2021-05-14T13:22:23Z
dc.date.issued
2011
dc.identifier.citation
Gonzalez, Jimena Soledad; Alvarez, Vera Alejandra; Poly (vinyl alcohol) hydrogels: Influence of processing variables on general behavior and drug release device performance; Nova Science Publishers; 10; 2011; 265-285
dc.identifier.isbn
978-1-61324-511-8
dc.identifier.uri
http://hdl.handle.net/11336/132075
dc.description.abstract
Poly (vinyl alcohol) (PVA) hydrogels have a number of interesting properties whose make it an excellent candidate for several applications. One of the well known uses of these materials is like drug delivery device for their high hydrophilicity and water uptake capability. Hydrogels of PVA were obtained by two different routes: chemical method (by using a crosslinking agent, such as glutaraldehyde (GA)) and by physical method (carried out by freezing/thawing (F/T), resulting in cryogels). The main advantages of F/T are its easiness that does require neither high temperatures nor toxic agents as waste that can be harmful to the human body. It is possible, for biomedical applications, that un-reacted residue from the crosslinking agent may eluted slowly over time resulting in the release of toxic agents; being this toxicity undesirable for pharmaceutical applications because the activity of the drug or agent being released could be destroyed. The properties of PVA hydrogels depend mainly on their density or degree of crosslinking and crystallinity. Nevertheless, it is still unclear what role of processing variables play on the significant properties of the material. These properties can be driven by the numbers of F/T cycles, the cycle extent, the freezing temperature, the rate of thawing, the polymer concentration and its molecular weight (Mw). The aim of this chapter was to analyze the effect of some processing variables on the characteristic and properties of PVA hydrogels and to look at the delivery system behavior in aspirin and ibuprofen drugs. For this purpose, cryogels with different: numbers of F/T cycles (1 to 4), cycles extent (1, 12 and 24 h), Mw (18000; 40500, 93500 and 155000 g/mol) and polymer concentration (5 to 15 wt.%) were synthesized and 266 Jimena Soledad Gonzalez and Vera Alejandra Alvarez analyzed by means of thermogravimetric analysis (TGA), differential scanning calorimetric (DSC), swelling studies, X-ray diffraction (XRD), rheological tests and mechanical properties. In addition, cryogels were compared with chemically based hydrogels by means of selected characterization techniques. The results obtained in the present study suggest that it is possible to obtain cryogels with controlled properties and to be optimist about the future use of these kinds of hydrogels, avoiding the use of toxic crosslinking agent, for applications such as drug delivery.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Nova Science Publishers
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Poly (vinyl alcohol)
dc.subject
Hydrogels
dc.subject
Drug release
dc.subject.classification
Ingeniería de los Materiales
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dc.subject.classification
Ingeniería de los Materiales
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dc.subject.classification
INGENIERÍAS Y TECNOLOGÍAS
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dc.title
Poly (vinyl alcohol) hydrogels: Influence of processing variables on general behavior and drug release device performance
dc.type
info:eu-repo/semantics/publishedVersion
dc.type
info:eu-repo/semantics/bookPart
dc.type
info:ar-repo/semantics/parte de libro
dc.date.updated
2021-03-12T20:09:08Z
dc.journal.volume
10
dc.journal.pagination
265-285
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
New York
dc.description.fil
Fil: Gonzalez, Jimena Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
dc.description.fil
Fil: Alvarez, Vera Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.novapublishers.org/catalog/product_info.php?products_id=24210
dc.conicet.paginas
300
dc.source.titulo
Advances in Materials Science Research
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