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Artículo

Full-length galectin-8 and separate carbohydrate recognition domains: the whole is greater than the sum of its parts?

Cagnoni, AlejandroIcon ; Troncoso, María FernandaIcon ; Rabinovich, Gabriel AdriánIcon ; Mariño, Karina ValeriaIcon ; Elola, María T.
Fecha de publicación: 06/2020
Editorial: Portland Press
Revista: Biochemical Society Transactions
ISSN: 0300-5127
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Bioquímica y Biología Molecular; Bioquímica y Biología Molecular

Resumen

Galectin-8 (Gal-8) is a tandem-repeat type galectin with affinity for β-galactosides, bearing two carbohydrate recognition domains (CRD) connected by a linker peptide. The N- and C-terminal domains (Gal-8N and Gal-8C) share 35% homology, and their glycan ligand specificity is notably dissimilar: while Gal-8N shows strong affinity for α(2-3)-sialylated oligosaccharides, Gal-8C has higher affinity for non-sialylated oligosaccharides, including poly-N-acetyllactosamine and/or A and B blood group structures. Particularly relevant for understanding the biological role of this lectin, full-length Gal-8 can bind cell surface glycoconjugates with broader affinity than the isolated Gal-8N and Gal-8C domains, a trait also described for other tandem-repeat galectins. Herein, we aim to discuss the potential use of separate CRDs in modelling tandem-repeat galectin-8 and its biological functions. For this purpose, we will cover several aspects of the structure?function relationship of this protein including crystallographic structures, glycan specificity, cell function and biological roles, with the ultimate goal of understanding the potential role of each CRD in predicting full-length Gal-8 involvement in relevant biological processes.
Palabras clave: CELL BINDING , CRYSTALLOGRAPHY , GALECTIN-8 , GLYCAN ARRAY , GLYCAN SPECIFICITY , SIALYLATION
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/131958
URL: https://portlandpress.com/biochemsoctrans/article-abstract/48/3/1255/225549/Full
DOI: http://dx.doi.org/10.1042/BST20200311
Colecciones
Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Citación
Cagnoni, Alejandro; Troncoso, María Fernanda; Rabinovich, Gabriel Adrián; Mariño, Karina Valeria; Elola, María T.; Full-length galectin-8 and separate carbohydrate recognition domains: the whole is greater than the sum of its parts?; Portland Press; Biochemical Society Transactions; 48; 3; 6-2020; 1255-1268
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