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dc.contributor.author
Menendez, Javier A.
dc.contributor.author
Peirce, Susan K.
dc.contributor.author
Papadimitropoulou, Adriana
dc.contributor.author
Cuyàs, Elisabet
dc.contributor.author
Steen, Travis Vander
dc.contributor.author
Verdura, Sara
dc.contributor.author
Vellón, Luciano
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dc.contributor.author
Chen, Wen Y.
dc.contributor.author
Lupu, Ruth
dc.date.available
2021-05-13T12:11:10Z
dc.date.issued
2020-12
dc.identifier.citation
Menendez, Javier A.; Peirce, Susan K.; Papadimitropoulou, Adriana; Cuyàs, Elisabet; Steen, Travis Vander; et al.; Progesterone receptor isoform-dependent cross-talk between prolactin and fatty acid synthase in breast cancer; Impact Journals; Aging; 12; 24; 12-2020; 24671-24692
dc.identifier.issn
1945-4589
dc.identifier.uri
http://hdl.handle.net/11336/131957
dc.description.abstract
Progesterone receptor (PR) isoforms can drive unique phenotypes in luminal breast cancer (BC). Here, we hypothesized that PR-B and PR-A isoforms differentially modify the cross-talk between prolactin and fatty acid synthase (FASN) in BC. We profiled the responsiveness of the FASN gene promoter to prolactin in T47Dco BC cells constitutively expressing PR-A and PR-B, in the PR-null variant T47D-Y cell line, and in PR-null T47D-Y cells engineered to stably re-express PR-A (T47D-YA) or PR-B (T47D-YB). The capacity of prolactin to up-regulate FASN gene promoter activity in T47Dco cells was lost in T47D-Y and TD47-YA cells. Constitutively up-regulated FASN gene expression in T47-YB cells and its further stimulation by prolactin were both suppressed by the prolactin receptor antagonist hPRL-G129R. The ability of the FASN inhibitor C75 to decrease prolactin secretion was more conspicuous in T47-YB cells. In T47D-Y cells, which secreted notably less prolactin and downregulated prolactin receptor expression relative to T47Dco cells, FASN blockade resulted in an augmented secretion of prolactin and up-regulation of prolactin receptor expression. Our data reveal unforeseen PR-B isoform-specific regulatory actions in the cross-talk between prolactin and FASN signaling in BC. These findings might provide new PR-B/FASN-centered predictive and therapeutic modalities in luminal intrinsic BC subtypes
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Impact Journals
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ENDOCRINE THERAPY
dc.subject
G129R
dc.subject
LUMINAL BREAST CANCER
dc.subject
PROLACTIN RECEPTOR
dc.subject.classification
Bioquímica y Biología Molecular
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Progesterone receptor isoform-dependent cross-talk between prolactin and fatty acid synthase in breast cancer
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-04-22T20:05:51Z
dc.journal.volume
12
dc.journal.number
24
dc.journal.pagination
24671-24692
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
New York
dc.description.fil
Fil: Menendez, Javier A.. Institut Català d'Oncologia; España. Institut d’Investigació Biomèdica de Girona; España
dc.description.fil
Fil: Peirce, Susan K.. Clemson University. Pearce Center Professional Communication; Estados Unidos
dc.description.fil
Fil: Papadimitropoulou, Adriana. Biomedical Research Foundation Academy of Athens; Grecia
dc.description.fil
Fil: Cuyàs, Elisabet. Institut Català d'Oncologia; España. Institut d’Investigació Biomèdica de Girona; España
dc.description.fil
Fil: Steen, Travis Vander. Mayo Foundation for Medical Education and Research. Mayo Clinic; Estados Unidos
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Fil: Verdura, Sara. Institut Català d'Oncologia; España. Institut d’Investigació Biomèdica de Girona; España
dc.description.fil
Fil: Vellón, Luciano. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Chen, Wen Y.. Clemson University; Estados Unidos
dc.description.fil
Fil: Lupu, Ruth. Mayo Foundation for Medical Education and Research. Mayo Clinic; Estados Unidos. Clemson University; Estados Unidos. Mayo Clinic Cancer Center; Estados Unidos
dc.journal.title
Aging
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.18632/aging.202289
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.aging-us.com/article/202289/text
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