Artículo
Characterization of a neutralizing anti-human galectin-1 monoclonal antibody with angioregulatory and immunomodulatory activities
Pérez Sáez, Juan Manuel
; Hockl, Pablo Francisco
; Cagnoni, Alejandro
; Mendez Huergo, Santiago Patricio
; García, Pablo Alfredo
; Gatto, Sabrina Gisela
; Cerliani, Juan Pablo
; Croci Russo, Diego Omar
; Rabinovich, Gabriel Adrián
Fecha de publicación:
10/2021
Editorial:
Springer
Revista:
Angiogenesis
ISSN:
0969-6970
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Galectins, a family of highly conserved β-galactoside-binding proteins, control tumor progression by modulating different hallmarks of cancer. Galectin-1 (Gal-1), a proto-type member of this family, plays essential roles in tumor angiogenesis and immunosuppression by cross-linking glycosylated receptors on the surface of endothelial and immune cells. Targeted disruption of Gal-1 suppresses tumor growth by counteracting aberrant angiogenesis and reinforcing antitumor immunity in several experimental settings. Given the multiple therapeutic benefits associated with Gal-1 blockade, several Gal-1 inhibitors, including glycan-based competitors, antagonistic peptides, aptamers and neutralizing monoclonal antibodies, have been designed and evaluated in pre-clinical tumor models. Here we report the biochemical and functional characterization of a newly developed neutralizing anti-human Gal-1 monoclonal antibody (Gal-1-mAb3), which specifically recognizes a unique epitope in Gal-1 protein and exerts both angioregulatory and immunomodulatory activities. Blockade of Gal-1 function using Gal-1-mAb3, might be relevant not only in cancer but also in other pathologic conditions characterized by aberrant angiogenesis and uncontrolled immunosuppression.
Palabras clave:
ANGIOGENESIS
,
GALECTIN-1
,
IMMUNOREGULATION
,
NEUTRALIZING ANTIBODY
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Colecciones
Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Citación
Pérez Sáez, Juan Manuel; Hockl, Pablo Francisco; Cagnoni, Alejandro; Mendez Huergo, Santiago Patricio; García, Pablo Alfredo; et al.; Characterization of a neutralizing anti-human galectin-1 monoclonal antibody with angioregulatory and immunomodulatory activities; Springer; Angiogenesis; 24; 1; 10-2021; 1-5
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