Show simple item record Gonzalez, Claudio D. Lee, Myung Shik Marchetti, Piero Pietropaolo, Massimo Towns, Roberto Vaccaro, Maria Ines Watada, Hirotaka Wiley, John W. 2017-02-20T21:00:37Z 2011-01
dc.identifier.citation Gonzalez, Claudio D.; Lee, Myung Shik; Marchetti, Piero; Pietropaolo, Massimo; Towns, Roberto; et al.; The emerging role of autophagy in the pathophysiology of diabetes mellitus; Landes Bioscience; Autophagy; 7; 1; 1-2011; 2-11
dc.identifier.issn 1554-8627
dc.description.abstract An emerging body of evidence supports a role for autophagy in the pathophysiology of type 1 and type 2 diabetes mellitus. Persistent high concentrations of glucose lead to imbalances in the antioxidant capacity within the cell resulting in oxidative stress-mediated injury in both disorders. An anticipated consequence of impaired autophagy is the accumulation of dysfunctional organelles such as mitochondria within the cell. Mitochondria are the primary site of the production of reactive oxygen species (ROS), and an imbalance in ROS production relative to the cytoprotective action of autophagy may lead to the accumulation of ROS. Impaired mitochondrial function associated with increased ROS levels have been proposed as mechanisms contributing to insulin resistance. In this article we review and interpret the literature that implicates a role for autophagy in the pathophysiology of type 1 and type 2 diabetes mellitus as it applies to β-cell dysfunction, and more broadly to organ systems involved in complications of diabetes including the cardiovascular, renal and nervous systems.
dc.format application/pdf
dc.language.iso eng
dc.publisher Landes Bioscience
dc.rights info:eu-repo/semantics/restrictedAccess
dc.subject AUTOPHAGY
dc.subject.classification Patología
dc.subject.classification Medicina Básica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.title The emerging role of autophagy in the pathophysiology of diabetes mellitus
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion 2017-02-15T14:08:45Z
dc.journal.volume 7
dc.journal.number 1
dc.journal.pagination 2-11
dc.journal.pais Estados Unidos
dc.journal.ciudad Austin
dc.description.fil Fil: Gonzalez, Claudio D.. Hospital CEMIC; Argentina. Universidad de Buenos Aires; Argentina
dc.description.fil Fil: Lee, Myung Shik. Samsung Medical Center; Corea del Sur
dc.description.fil Fil: Marchetti, Piero. Universita Degli Studi Di Pisa; Italia
dc.description.fil Fil: Pietropaolo, Massimo. University Of Michigan; Estados Unidos
dc.description.fil Fil: Towns, Roberto. University Of Michigan; Estados Unidos
dc.description.fil Fil: Vaccaro, Maria Ines. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
dc.description.fil Fil: Watada, Hirotaka. Juntendo University. School of Medicine; Japón
dc.description.fil Fil: Wiley, John W.. University Of Michigan; Estados Unidos
dc.journal.title Autophagy
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/

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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)